不同方法口服非洛地平治疗高血压的疗效观察  

Effects of felodipine taken with different methods in the treatment of hypertension

作　　者：林晨萍[1] 阮宏标[1] 张海燕[1] 李青松[1] 

机构地区：[1]玉环县人民医院心内科,浙江玉环317600

出　　处：《全科医学临床与教育》2007年第2期116-118,共3页Clinical Education of General Practice

摘　　要：目的比较两种不同方法服用非洛地平对24h动态血压的影响，从而寻求一种较好的服药方法，以获得良好的降压效应。方法120例1-2级高血压患者随机分成A组和B组，A组每晨6时口服非洛地平10mg。B组每晨6时、下午4时分别口服非洛地平5mg，比较两组患者4周服药后平均血压下降值、血压负荷、平滑指数。评价降压效果。结果服药后两组患者的24h平均收缩压、平均舒张压、白昼平均收缩压、平均舒张压均较服药前有明显下降，但两组间比较，差异均无统计学意义（t分别=0．89、1．01、0．55和0．73，P均〉0．05）。B组夜间平均收缩压、平均舒张压、24h收缩压血压负荷、舒张压血压负荷、夜间收缩压血压负荷、舒张压血压负荷低于A组，两组间比较，差异均有统计学意义（t分别=2．11、2．05、3．02、2．95、5．52和8．20，P均〈0．05）。A组收缩压平滑指数为1．12±0．54，舒张压平滑指数为1．02±0．42，B组收缩压平滑指数为1．32±0．62，舒张压平滑指数为1．24±0．46，B组大于A组，两组比较，差异均有统计学意义（t=3，85、2.75，P均〈0．05）。结论两种方法口服非洛地平均能控制1-2级高血压患者24h血压，在平稳降压方面非洛地平5mg早晚两次口服优于非洛地平10mg每晨一次口服。Objective To compare the impact of two different methods of taking feledipine on 24 - hour ambulatory blood pressure, to find a better antihypertensive effect. Methods One hundred twenty patients with grade 1 or 2 hypertension were randomly divided into group A and group B, Group A took 10 mg of feledipine at 6：00 am, while group B take 5rag of felodipine at 6：00 am and 16：00 pm. Four weeks later, the decreased value of the average blood pressure, blood pressure load, the smoothness index, and blood pressure evaluation of the patients between group A and group B were compared. Results There was a marked decline in the average systolic and diastolic blood pressure of 24 hours and average systolic and diastolic blood pressure in daytime . There was no significant difference between the two groups （t = 0.89, 1.01, 0.55, 0.73, P 〉 0.05） . The average systolic and diastolic blood pressure in night time and the 24 systolic blood pressure load and diastolic blood pressure load of group B were lower than that of group A. The systolic blood pressure load and diastolic blood pressure load in night of group B were lower than that of group A, the difference between the two groups was statistically significant（ t = 2.11,2.05, 3.02, 2.95,5.52,8.20, P 〈 0.05） . The systolic smoothness index was 1.12 ± 0.54 and the diastolic smoothness index was 1.02 ± 0.42 in group A, while the systolic smoothness index was 1.32 ± 0.62 and the diastolic smoothness index was 1.24 ± 0.46 in group B. The difference between the two groups was statistically significant（ t = 3.85,2.75, P 〈 0.05）. Conclusions Both the different methods of taking felodipine can control the average 24 - hour blood pressure in patients with grade 1 or 2 hypertension. But taking felodipine 5 rag orally twice is superior to taking felodipine 10 mg every morning in smooth control.

关 键 词：非洛地平 高血压 动态血压 

分 类 号：R544.1[医药卫生—心血管疾病]