壳聚糖衍生物——N-三甲基壳聚糖的促吸收作用研究进展  

Advances in research on absorption-enhancing effects of N-trimethyi chitosan chloride

作　　者：赵军[1] 刘其凤[2] 

机构地区：[1]山东省胜利石油管理局肛肠病防治院药剂科,山东东营257077 [2]山东省胜利石油管理局胜北医院药剂科,山东东营257064

出　　处：《药学服务与研究》2007年第2期106-109,共4页Pharmaceutical Care and Research

摘　　要：目的:探讨壳聚糖衍生物——N-三甲基壳聚糖促吸收作用的研究进展。方法:查阅国内外有关N-三甲基壳聚糖促吸收作用的机制、影响因素及应用的文献,并进行分析、总结。结果:N-三甲基壳聚糖可增加细胞旁路途径的跨膜转运,具有促进药物吸收的作用。结论:N-三甲基壳聚糖有望作为一种有效促吸收剂应用于药物制剂。Objective： To study the advances in research on absorption-enhancing effects of chitosan derivative-N-trimethyl chitosan chloride. Methods：The related literature at home and abroad on the mechanism,influential factors and application of N-trimethyl chitosan chloride as an absorption enhancer was collected and analysed. Results： N-trimethyl chitosan chloride could enhance transmemhrane transport of drugs via the paracellular route,and it possessed the enhancing absorption properties. Conclusion： N-trimethyl chitosan chloride may he used as an absorption enhancer in pharmaceutical preparation.

关 键 词：N-三甲基壳聚糖 吸收 佐剂 药物 药物载体 综述 

分 类 号：R943.5[医药卫生—药剂学]