血管性血友病因子在ABO血型个体中质和量差异的实验研究  

Differences of Quality and Quantity of the von Willebrand Factor on the ABO Blood Group in Laboratory Parameters

作　　者：徐海燕[1] 赵益明[1] 余自强[1] 阮长耿[1] 

机构地区：[1]江苏省血液研究所苏州大学附属第一医院,江苏苏州215006

出　　处：《中国血液流变学杂志》2007年第1期55-57,97,共4页Chinese Journal of Hemorheology

基　　金：苏州大学附属第一医院血液病学"135工程"重点学科开放课题基金资助项目(135XY0405);苏州市科技基金项目(SZD0607)

摘　　要：目的比较血管性血友病因子在ABO血型中质和量的差异。方法运用ELISA法同时测定A血型、B血型、AB血型及O血型四组正常人的vWF抗原水平(vWF:Ag)、VWF瑞斯托霉素辅因子活性(vWF:Rcof)及vWF胶原结合试验(vWF:CBA),并应用统计方法比较不同血型之间结果的差异。结果O型血个体其vWF:Ag、vWF:Rcof及vWF:CBA均低于非O型血,差异有显著统计学意义(P<0.001);同时,vWF:CBA下降水平大于vWF:Rcof,使得vWF:CBA/Ag(P<0.001)小于vWF:Rcof/Ag(P值为0.84)。结论O型血较非O型血个体有更高的出血危险,在临床诊断vWD的过程中要充分考虑ABO血型系统对血浆vWF水平的影响。Objective To compare the difference of quality and quantity of the von Willebrand factor on the ABO blood group.Methods We detect the levels ofvon Willebrand factor（vWF） antigen, vWF：ristocetin cofactor, vWF：collagen binding assay by ELISA in 42 blood group O and 101 non-group O blood donors who well-matched for sex and age distribution.Then we compare the differences of the results between the four blood groups by statistics method.Results There are conspicuous differences of vWF：Ag, vWF： Rcof and vWF：CBA between the O group individuals（P〈0.001）and non-O group.And reduction in vWF：CBA is greater than vWF：Rcof in O group donors. This lead to a lower vWF： CBA/Ag ratio （P〈0.001） in O group donors whereas the vWF： Rcof/Ag ratio （P=0.84） is unaffected.Conclusions The results showed that the O group individuals have a greater risk for bleeding than non-O group, we must consider the influence of ABO blood group to the plasma levels ofvWF during the vWD clinical diagnosis.

关 键 词：血管性血友病因子 血管性血友病 ABO血型 瑞斯托霉素辅因子活性 胶原结合试验 

分 类 号：R554.1[医药卫生—血液循环系统疾病]