HIV／AIDS患者外周血总淋巴细胞数与CD4^＋ T淋巴细胞数的相关性分析  

Analysis of the Correlation between Total Lymphocyte Counts and CD4^＋ T Lymphocyte Counts in Peripheral Blood of HIV/AIDS Patients

作　　者：常株洲[1] 陈伟烈[2] 袁小珍[2] 唐漾波[2] 

机构地区：[1]广州市第八人民医院检验科,广东广州510060 [2]广州市第八人民医院传染病研究所,广东广州510060

出　　处：《国际医药卫生导报》2007年第7期79-83,共5页International Medicine and Health Guidance News

摘　　要：目的探讨HIV／AIDS患者外周血总淋巴细胞数（total lymphocyte count，TLC）与CD4阳性（CD4^＋）T淋巴细胞数的相关性，了解用TLC预测CD4^＋T淋巴细胞数的可行性。方法分析602例HIV／AIDS患者共计1883例次TLC和CD4^＋T淋巴细胞数相关性，根据灵敏度、特异度、阳性预测值和阴性预测值，估计预测CD4〈100个／μlCD4〈200个／μlCD4〈350个／μlTLC的临界值。相关分析和回归分析采用SPSS13．0统计软件。结果TLC与CD4^＋T淋巴细胞数显著正相关（r=0．631，P〈0．001）。用TLC〈1200个／μl测CD4〈100个／μl敏度为70．3％，特异度为82．9％，阳性预测值为71％，阴性预测值为80．6％；TLC〈1500个／μl测CD4〈200个／μl敏度为71．1％，特异度为75．4％，阳性预测值为80．6％，阴性预测值为64．4％；用TLC〈1800个／μl测CD4〈350个／μl敏度为76．1％，特异度为75．9％，阳性预测值为92．7％，阴性预测值为45．1％。结论在无条件检测CD4^＋T淋巴细胞计数的情况下，可用TLC预测CD4^＋T淋巴细胞计数。分别以TLC〈1200个／μl〈1500个／μl〈1800个／μl测CD4〈100个／μl〈200个／μl〈350个／μl比较合适的。Objective To study the correlation between total lymphocyte count （TLC） and CD4^＋ T lymphocyte count in HIV/AIDS patients and to evaluate the application of TLC in predicting CD4^＋ T lymphocyte count. Methods Correlation between TLC and CD4 count was analyzed in 602 HIV/AIDS patients. The sensitivity, specificity, positive predictive value （PPV） and negative predictive value （NPV） of various TLC critical value were computed for CD4〈100 cells/μl, CD4〈200 cells/ μl and CD4〈350 cells/ μl. Correlation analysis and regression analysis was done using SPSS software. Results A significant positive linear correlation was noted between TLC and CD4^＋ T lymphocyte count（r=0. 631, P〈0. 001）.TLC〈1200 cells/ μl had a 70.3% sensitivity, 82.9% specificity, 71% PPV and 80.6% NPV for predicting CD4〈100 cells/ μl. TLC〈1500 cells/ μl had a 71.1% sensitivity, 75.4% specificity, 80.6% PPV and 64. 4% NPV for predicting CD4〈200 cells/ μl. TLC〈1800 cells/ μl had a 76.1% sensitivity, 75. 9% specificity, 92.7% PPV and 45.1% NPV for predicting CD4〈350 cells/ μl. Conclusion TLC may be used to predict CD4^＋ T lymphocyte count in resource-limited settings. It is reasonable to use TLC〈1200 cells/ μl,〈1500 cells/ μl and 〈1800 cells/ μl to predict CD4〈100 cells/ μl,〈200 cells/ μl and 〈350 cells/ μl.

关 键 词：获得性免疫缺陷综合征 CD4^+T淋巴细胞数 总淋巴细胞数 

分 类 号：R593[医药卫生—内科学]