皮肌炎/多发性肌炎心脏损害45例临床分析  

Clinical Study on the Cardiac Damage in Paitients with Polymyositis and Dermatomyositis:A Report of 45 Cases

作　　者：鱼云霞[1] 鱼慧霞 宫怡[1] 

机构地区：[1]宁夏医学院附属医院风湿科,银川750004 [2]宁夏石嘴山市大武口工业园区医院内科,大武口753000

出　　处：《宁夏医学院学报》2007年第2期135-136,142,共3页Journal of Ningxia Medical College

摘　　要：目的 探讨皮肌炎（DM）/多发性肌炎（PM）患者合并心脏损害的临床特点.方法 对我院2001～2005年住院治疗的97例DM/PM患者中合并心脏损害45例进行回顾性分析.结果 临床表现主要为程度不同的胸闷、心悸,心脏损害多见心律失常（60.0%）和ST-T异常最多见（57.8%）,其次为心包炎（28.9%）;DM/PM患者心脏损害的发生率与肌酸激酶同工酶（CK-MB）的升高有相关性（P＜0.01）;抗J0-1抗体阳性DM/PM患者87.5%出现心脏损害（P＜0.05）.结论 DM/PM患者合并心脏损害预后差;CK-MB的升高提示心脏损害,抗J0-1抗体阳性患者更易发生心脏损害.Objective To investigate clinical features of cardiac damage in paitients with Polymyositis（PM）/ Dermatomyositis（DM）. Methods 97 cases of PM/DM from 2001 to 2005 were retrospectively reviewed. Results Cardiac damage （46.4 % ）occurred in 45 out of 97 cases of PM/DM. clinical manifestations were different among the cases of cardiac damage, in which 60.0% arrhythmia, 57.8% ST-T abnomality,28.9% pericardium were involved. Increasing of CK-MB in the cases of PM/DM were significant related to having cardiac damage（ P 〈 0.01 ）. Rate of cardiac damage is 87.5 % in the anti-J0-1 positive PM/DM（ P 〈 0.05）. Conclusion Cardiac damage is common in paitients with PM/DM. The change of CK-MB may be related with cardiac damage and the anti-J0-1 positive PM/DM are more likely to have cardiac damage.

关 键 词：皮肌炎 多发性肌炎 心脏损害 

分 类 号：R593.26[医药卫生—内科学]