结核分枝杆菌临床分离株耐药性分析  

ANALYSIS ON DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS

作　　者：裴德翠[1] 王淑兰[1] 王湘[2] 王金勇[1] 王娅[1] 

机构地区：[1]湖北郧阳医学院,十堰442000 [2]十堰市疾病预防控制中心

出　　处：《现代预防医学》2007年第8期1429-1431,共3页Modern Preventive Medicine

摘　　要：[目的]了解肺结核分枝杆菌耐药性特点,为临床用药提供参考。[方法]收集2003年9月～2006年5月门诊痰菌阳性标本,获取培养阳性标本136份,采用绝对浓度间接法试验对全部培养阳性标本进行4种抗结核药物(RFP、INH、SM、EMB)的耐药性测定。[结果]总耐药率62.5%(85),初始耐药率47.1%(40),初始耐多药率31.8%(27),获得性耐药率88.2%(45),获得性耐多药率58.8%(30)。耐药顺序为RFP﹥INH﹥SM﹥EMB,耐药率分别为:51.5%,48.5%,26.5%,19.9%。[结论]本地结核菌耐药率远远高于全国平均耐药率(46%),因此应加强抗结核药物的耐药性监测,根据药敏结果选择有效化疗方案,彻底治疗结核病人。[Objective] To understand drug resistance characteristics of mycobacterium tuberculosis, and to provide reference for clinical medication. [ Methods] M. tuberculosis positive sputum samples from outpatients were collected from September 2003 to May 2006. 136 samples were affirmed. Drug resistance of samples against rifampicin （RFP）, isoniazid （ INH）, streptomycin （SM） and ethambutol （EMB） were tested by method of absolute concentration. [ Results] The total drug resistance rate was 62.5% （85）, the initial drug resistance rate was 47.1% （40）, the initial multi-drug resistance rate was 31.8% （27）, the acquired drug resistance rate were 88.2% （45）, and the acquired multi-drug resistance rate was 58.8% （30） . The resistance rates against INH, RFP, SM, and EMB were 51.5%, 48.5%, 26.5%, 19.9%, respectively. [Conclusions] Drug resistance rate in local is higher than the average drug resistance rate in country （46%） . To enhance drug resistance monitoring and to select medicine based on drug sensitivity test are important.

关 键 词：结核分枝杆菌 肺结核 耐药性 

分 类 号：R52[医药卫生—内科学]