芳香羧酸衍生物驱避剂活性测定及定量构效关系的研究  

Determination of Repellency of Aromatic Carboxylic Acid Derivatives to Housefly in Relationship to Quantitative Structure Activity

作　　者：薛飞群[1,2] 汪汉卿[1,2] 赵荣材[1,2] 杨瑾 王玉春 徐忠赞[1,2] 杜小丽 张继瑜[1,2] 

机构地区：[1]中国农业科学院中兽医研究所 [2]中国科学院兰州化学物理研究所

出　　处：《中国农业科学》1997年第1期77-83,共7页Scientia Agricultura Sinica

基　　金：国家"八五"攻关专题资助项目

摘　　要：用家蝇作为实验昆虫，测定了４０个芳香羧酸衍生物的驱避活性，并对其结果进行了定量构效关系的研究。结果显示，化合物Ｂ６、Ｂ８、Ｍ２、Ｅ６具有较高的驱避活性；沸点参数Ｂ是影响化合物驱避活性的主要因素。而化合物取代基的体积不应大于苯；取代基的亲脂性（ｌｏｇＰ）应在３．５０左右。The repellency of forty aromatic carboxylic acid derivatives to the houseflies (Musca domestica L.) was determined quantitatively through their behavioral respect and the QSAR (quantitative structure activity relationship) were analyzed using Hansch method. The results indicate that the derivatives B 6,B 8,M 2,E 6 have a higher repellency and the repellency is significantly correlated with the boiling coefficients. The volume of substituent radicals in the molecules of the compounds should not be larger than a benzene, and the most appropriate value of partition coefficient(logP)is about 3.50.

关 键 词：驱避剂 芳香羧酸衍生物 驱避活性 定量构效关系 

分 类 号：S859.795[农业科学—临床兽医学]