丙泊酚用于无痛胃镜检查对认知功能的影响  

Effect of propofol used for painless gastroscopy on cognitive function

作　　者：赵宏[1] 孙艺丹[1] 尹极峰[1] 

机构地区：[1]新疆医科大学第一附属医院麻醉科,乌鲁木齐市830054

出　　处：《临床麻醉学杂志》2007年第4期282-283,共2页Journal of Clinical Anesthesiology

摘　　要：目的研究不同剂量丙泊酚用于门诊无痛胃镜检查时对认知功能的影响。方法选择胃镜检查患者40例,随机均分为A、B两组。两组患者均在胃镜置入前静注芬太尼1μg/kg,3min后A组静注丙泊酚1mg/kg,B组静注丙泊酚1.7mg/kg。当患者对言语指令无反应和睫毛反射消失即意识消失时置入胃镜,SpO2始终保持在95%以上。全部患者于胃镜检查结束拔镜后5min行神经行为认知状态检查(NCSE),并在15min内完成。结果40例患者均完成胃镜检查后进行NCSE测试。两组间比较,计算能力及记忆能力差异有统计学意义(P<0.05)。结论丙泊酚1mg/kg用于门诊无痛胃镜检查,不仅提供满意的镇痛效果和检查条件,而且对认知功能无影响,NCSE适用于评估门诊无痛胃镜检查患者的认知功能状态。Objective To study the effect of propofol used for outpatient painless gastroscopy on cognitive function. Methods Forty patients scheduled for gastroscopy were randomly divided into group A and B. All patients were given fentanil 1μg/kg intravenously before gastroscope insertion. Three minutes later, propofol 1 mg/kg was injected intravenously in group A and propofol 1.7 mg/kg in group B. The gastroscope was inserted when patient showed unconsciousness and no reaction to dictation. SpO2 was kept above 95% throughout gastroscopy. All patients received neurobehavioral cognitive status examination （NCSE） test five minutes after gastroscopy examination was over and must finish it within 15 min. Results The ability of memory and calculation showed a statistical difference between group A and B （P〈0.05）. Conclusion Propofol 1 mg/kg used for painless gastroscopy has no effect on cognitive function. NCSE is suitable for evaluation of outpatient＇s cognitive function.

关 键 词：丙泊酚 无痛胃镜检查 认知功能 

分 类 号：R614[医药卫生—麻醉学]