慢性乙型肝炎的Th细胞亚群及相关细胞因子网络失衡  

Research advances in the imbalance of helper T lymphocyte subpopulations and cytokine network in patients with chronic hepatitis B

作　　者：游晶[1] 庄林[2] 马永良[2] 唐宝璋[1] 

机构地区：[1]昆明医学院第一附属医院感染病科,云南省昆明市650032 [2]昆明市第三人民医院肝病科,云南省昆明市650041

出　　处：《世界华人消化杂志》2007年第8期791-799,共9页World Chinese Journal of Digestology

摘　　要：辅助性T细胞(helper T cell,Th细胞)是根据功能分类的一个T细胞亚群,根据所分泌细胞因子的不同,Th细胞可分为Th0、Th1、Th2和Th3 4种亚群,其中研究最多的是Th1和Th2两个亚群．Th1／Th2细胞及其细胞因子网络的调节对维持机体正常的免疫功能至关重要．乙型肝炎病毒(HBV)感染机体后,多种因素影响Th细胞增殖并且调节其亚型比例,细胞因子网络受到破坏,在细胞因子介导下便可造成肝脏等组织和器官的损害,直接或间接地影响到乙型肝炎发病及其转归．Helper T （Th） lymphocytes, important immune regulating cells of organism, could be divided into four functional subsets, Th0, Th1, Th2, Th3, on the basis of the immunoregulatory cytokines that these clones produced. Most of the current work in this field is exploratory and focuses on Th1 and Th2 subsets. Th1 cells secrete interferon-γ （IFN-γ）, interkeukin-2 （IL-2） and tumor necrosis factor-β and are principally involved in cell-mediated immunity. They play an important role in the protection against intracellular pathogens, including a variety of viruses. Th2 cells secret interleukin-4 （IL-4）, IL-5, IL-6 and IL-10 and regulate the humoral immune response. Th0 cells are naive Th cells, secreting Th1/Th2 phenotype cytokines at low levels. However, Th3 cells, which secrete active transforming growth factor-β, exert a negative immunoregulatory action on the immune response. The cross-regulatory properties of Th1 and Th2 subset cells and relevant cytokines network are very important to maintain normal immunity of organisms. HBV can destroy the balance of Th lymphocytes and cytokines network. The imbalance of pro-inflammatory Th1 and anti-inflammatory Th2 cytokine production play an important role in the immunopathogenesis of hepatitis B virus infection and alter chronic liver disease development, progression and outcome.

关 键 词：慢性乙型肝炎 乙型肝炎病毒 辅助性T细胞 细胞因子网络 免疫 

分 类 号：R512.62[医药卫生—内科学]