TGF-β1与慢性乙型肝炎的关系  

Relationship between transforming growth factor β1 and chronic hepatitis B

作　　者：游晶[1] 袁丽芳[1] 陈红英[1] 唐宝璋[1] 王辉[1] 

机构地区：[1]昆明医学院第一附属医院感染病科,云南省昆明市650032

出　　处：《世界华人消化杂志》2007年第8期869-872,共4页World Chinese Journal of Digestology

摘　　要：转化生长因子β(transforming growth factorβ, TGF-β)是一簇功能相似的活性多肽,具有多种生物活性,能调节多种细胞分化、增殖、迁移、及细胞外基质合成与降解,其中最受关注且与肝脏疾病关系最密切的是TGF-β1, TGF-β1在体内的水平高低及其基因多肽性都与各种乙型肝炎存在着密切的相关性．本文就TGF-β1与各种慢性乙型肝炎的关系作一综述．Transforming growth factor-β （TGF-β） is a family of related proteins that regulate many ceUular processes including growth, differentiation, extracellular matrix formation and breaking down and immunosuppression. TGF-β1 is considered to play a pivotal role in hepatic steUate cell activation and a confirmed role in liver fibrosis, and its antiproliferative, proapoptotic, and immunosuppressive activities can play important roles in the pathogenesis of viral hepatitis. There is a marked correlation between the concentration and gene polymorphisms of TGF-β1 and chronic hepatitis B.

关 键 词：转化生长因子Β1 乙型肝炎 乙型肝炎病毒 TGF-Β1 

分 类 号：R512.62[医药卫生—内科学]