CD4^＋T淋巴细胞的活化在HIV-1感染长期非进展者及典型进展者之间差异的研究  

Difference in the CD4^＋ T lymphocytes＇ activation between long term non-progressors and typical progressors of HIV-1 infected patients

作　　者：焦艳梅[1] 福军亮[2] 张政[2] 张晖[2] 金磊[2] 周春保[2] 付宝云[2] 王福生[2] 吴昊[1] 

机构地区：[1]首都医科大学附属北京佑安医院, 100054 [2]解放军第三0二医院生物治疗研究中心

出　　处：《中华实验和临床病毒学杂志》2007年第1期11-13,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：北京市科委资助项目（D0906003040391）;国家973资助项目（2006CB504201,2006CB504305）

摘　　要：目的 了解CD4^＋T淋巴细胞的活化在长期感染非进展者（LTNP）及典型进展者（TP）之间的差异，探讨HIV感染的免疫基础。方法 收集24例HIV-1感染患者（7名LTNP患者，17名TP患者）及15例健康对照的抗凝血标本，流式细胞术检测CD4^＋T淋巴细胞的活化标志物CD38并检测其CD4计数等指标；bDNA方法检测患者体内的病毒载量。结果 与正常人相比，LTNP患者的CD4^＋T淋巴细胞的活化的差异无统计学意义（P〉0．05）而TP患者的活化程度明显增高（P〈0．01）；HIV感染者CD4^＋T淋巴细胞CD38的表达水平与CD4计数呈正相关，与病毒载量呈负相关。结论 随着疾病的进展，CD4^＋T淋巴细胞的活化程度逐渐增高；LTNP患者CD4^＋T淋巴细胞的活化程度没有明显增高可能是其疾病长期不进展的原因之一。Objective To investigate the difference in the CD4^＋ T lymphocytes＇activation between long term non progressors （LTNP） and typical progressors （TP） of HIV-1 infected patients. Methods Twenty-four HIV-1 infected patients and 15 heathy control adults were tested and flow cytometry was used to detect the activation marker CD38 and CD4 count in blood samples taken from the patients and control, bDNA method was used to test the virus load in the plasma of patients. Results The activation of CD4^＋ T cells was positively correlated with virus load and negatively correlated with CD4 counts. Compared with normal controls, the activation of CD4^＋ T cells was obviously increased in TP patients but not obviously changed in LTNP patients. Conclusion Compared with healthy controls, the activation of CD4^＋ T cells in LTNP did not obviously increase. This maybe partially accounts for LTNP patients keeping a good state for a long time.

关 键 词：HIV-1 免疫活性 抗原 CD38 

分 类 号：R686[医药卫生—骨科学]