透皮促渗剂对吲哚美辛和沙丁胺醇透皮作用的影响  

Effect of transdermal penetration enhancers on permeation ability of indomethacin and salbutamol

作　　者：王斐[1] 丁雪鹰[1] 高静[1] 高申[1] 

机构地区：[1]第二军医大学药学院药剂学教研室,上海200433

出　　处：《第二军医大学学报》2007年第4期421-424,共4页Academic Journal of Second Military Medical University

摘　　要：目的:研究不同透皮促渗剂对吲哚美辛和沙丁胺醇体外经皮渗透的促进作用。方法:用Valia-Chien水平扩散池,选择氮酮、丙二醇、N-甲基-吡咯烷酮、油酸、薄荷油、氮酮与丙二醇合用作为促进剂,离体SD大鼠腹部皮肤用促渗剂预处理,紫外分光光度法测定接收液中的药物含量。结果:与空白对照组比较,除了丙二醇对吲哚美辛和沙丁胺醇体外经皮渗透有抑制作用外,其余促进剂均显著提高二者的渗透速率(P<0．01),尤其以氮酮与丙二醇合用的促渗效果最好,吲哚美辛、沙丁胺醇的渗透速率分别达125．91、155．94μg·cm-2·h-1。结论:氮酮与丙二醇合用、氮酮、N-甲基-吡咯烷酮、油酸、薄荷油可作为促渗剂用于复方吲哚美辛的透皮制剂。Objective：To study the effect of different transdermal penetration enhancers on the skin permeation ability of indomethacin and salbutamol in vitro. Methods： Valia-Chien diffusion cell was adopted as the apparatus for in vitro skin permeation test. Excised SD-rat abdomen skin was pretreated with penetration enhancers including Azone, Propylene glycol, N- methylpyrrolidone, oleic acid, peppermint oil, and a combination of Azone and Propylene glycol. A UV method was established to determine the contents of indomethacin and salbutamol in receiver diffusion cells. Results： Compared with blank control group, all the enhancers showed significant enhancement effect on the permeability of indomethacin and salbutamol except for propylene glycol （P 〈 0. 01）. Azone combined with propylene glycol showed the greatest ability to enhance the flux of indomethacin（125.91 μg·cm^-2·h^-1） and salbutamol（155.94μg·cm^-2·h^-1）. Conclusion： Azone combined with Propylene glycol, Azone,N-methylpyrrolidone, Oleic acid, and Peppermint oil can be used as penetration enhancers in the transdermal preparation of compound indomethacin.

关 键 词：吲哚美辛 沙丁胺醇 透皮促渗剂 皮肤吸收 

分 类 号：R971.1[医药卫生—药品]