二杈狗牙花化学成分的研究(Ⅱ)  

Study on chemical constituents of Tabernaemontana divaricata (Ⅱ)

作　　者：梁爽[1] 陈海生[1] 王厚鹏[1] 金丽[1] 乔丽茗[1] 卢嘉[1] 

机构地区：[1]第二军医大学药学院天然药物化学教研室,上海200433

出　　处：《第二军医大学学报》2007年第4期425-426,共2页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(20272081)~~

摘　　要：目的:对二杈狗牙花根茎的化学成分进行分离及结构鉴定。方法:利用各种色谱技术进行分离,根据理化性质及波谱学方法进行结构鉴定。结果:分离得到6个化合物,二十八酸二甘油酯[bis(2,3-dihydroxypropyl)octacosanedioate,1],正三十四垸醇(tetratriacontanol,2),棕榈酸(palmitic acid,3),单棕榈酸甘油酯(glycerol monopalmitate,4),β-谷甾醇(β-sitosterol, 5),β-胡萝卜苷(daucosterol,6)。结论:化合物1为新化合物,化合物2～4均为首次从该属植物中分离得到。Objective： To extract and identify the chemical constituents in the roots and stems of Tabernaernontana divaricata. Methods： The solvent extraction and silica column chromatography were used to separate the chemical constituents, and their structures were identified by physicochemical properties and spectra analysis. Results： Six compounds were isolated and their structures were identified as bis （2,3-dihydroxypropyl） octacosanedioate （ 1 ）, tetratriacontanol （2）, palmitic acid （3）, glycerol monopalmitatel （4）,β-sitosterol （5）, and β-daucosterol （6）. Conclusion ： Compound 1 is a new glyceroester ; compounds 2,3 and 4 are isolated from Tabernaernontana genus for the first time.

关 键 词：二权狗牙花 分离和提纯 中药鉴定 二十八酸二甘油酯 

分 类 号：R282.71[医药卫生—中药学]