噪声性听损失与耳蜗内神经递质改变的研究进展  

Noise-induced hearing loss and cochlea neurotransmitters:recent progress

作　　者：张琰敏[1] 马蓓[1] 高文元[1] 

机构地区：[1]第二军医大学基础部生理学教研室,上海200433

出　　处：《第二军医大学学报》2007年第4期430-433,共4页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30570444)~~

摘　　要：螺旋神经节细胞(spiral ganglion neuron,SGN)是听觉传导通路中的初级神经元,与毛细胞形成传入性突触,在听觉的分析和整合中起到十分重要作用。其间存在多种神经递质,在生理和病理的情况下介导不同的效应,其机制较为复杂。本文就目前已知的耳蜗内神经递质如谷氨酸、三磷酸腺苷、多巴胺和γ-氨基丁酸等的特性及其在噪声性听力损失(noise-induced hearing loss,NIHL)中的作用和可能机制作一综述．以期为探究更多的内耳疾病的发生机制和治疗方法提供新的线索和依据。Being the primary neurons in the auditory system, spiral ganglion neurons form the afferent synapse with hair cells and play a critical role in the analysis and integration of hearing. Many kinds of neurotransmitters can be found in the cochlear and they have different effects under both physiological and pathological conditions with complicated mechanism. This article reviews the characters of some transmitters in cochlear, such as glutamate, ATP, dopamine and GABA, and their roles in noise-induced hearing loss, hoping to provide more clues for research and therapy of inner ear diseases.

关 键 词：听觉丧失 噪声性 螺旋神经节 耳蜗 谷氨酸 腺苷三磷酸 多巴胺 Γ氨基丁酸 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]