辛夷挥发油纳米脂质体的药理作用初探  

Pharmacologic action of the Magnolia biondii Pamp volatile oil nanometer bangosome

作　　者：吴敏[1] 路薇薇[1] 张欣[1] 

机构地区：[1]上海交通大学医学院新华医院中医科,上海200092

出　　处：《上海交通大学学报（医学版）》2007年第4期392-394,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科委纳米专项基金(0452nm057)~~

摘　　要：目的对辛夷挥发油纳米脂质体药理作用进行初步研究。方法通过观察辛夷挥发油纳米脂质体对小鼠耳肿胀、小鼠毛细血管渗出率和变应性鼻炎大鼠过敏症状的影响,对其药理作用进行初步研究。结果辛夷挥发油纳米脂质体能显著减轻二甲苯所致小鼠耳肿胀程度,能显著抑制醋酸所致的小鼠毛细血管通透性增加,并能有效对抗大鼠过敏性鼻炎所产生的鼻痒、喷嚏和流涕症状,疗效优于辛夷挥发油。结论辛夷挥发油纳米脂质体有较好的抗炎、抗过敏作用,采用纳米技术对传统辛夷进行加工可以显著提高其功效。Objective To investigate the pharmacologic action of the Magnolia biondii Pamp volatile oil nanometcr bangosome. Methods The pharmacologic action of the Magnolia biondii Pamp volatile oil nanometer bangosome was evaluated by observing its effect on Jimpy mice with swelling ear, capillary permeability and rats with allergic symptoms. Results The Magnolia biondii Pamp volatile oil nanometer bangosome could significantly relieve the degree of swelling in Jimpy mice extended by p-xylene, inhibit the increased capillary permeability in Jimpy mice extended by HAC, and combat the symptoms of rhinocnesmus, sneezing, nasal discharge with a better effect than the Magnolia biondii Pamp volatile oil. Conclusion The Magnolia biondii Pamp Volatile oil nanometer bangosome has a good antiinflammation and anti-hypersensitiveness effect, which upgrades the effect of the Magnolia biondii Pamp volatile oil.

关 键 词：辛夷挥发油 纳米脂质体 耳肿胀 毛细血管渗出率 过敏性鼻炎 

分 类 号：R285.5[医药卫生—中药学]