肝肾疾病对血浆同型半胱氨酸水平的影响  

The Effect of Hepatic and Renal Diseases on Plasma Homocysteine Level

作　　者：胡强[1] 马岚青[2] 赵莹[3] 黄尤光[4] 李树德[4] 

机构地区：[1]昆明医学院第二附属医院急诊科,云南昆明650101 [2]昆明医学院第一附属医院消化内科,云南昆明650032 [3]昆明医学院第一附属医院检验科,云南昆明650032 [4]昆明医学院生物化学教研室,云南昆明650031

出　　处：《昆明医学院学报》2007年第2期99-101,107,共4页Journal of Kunming Medical College

摘　　要：目的探讨肝脏和肾脏在同型半胱氨酸(Hcy)代谢中的作用.方法选择健康正常人55例,肝硬化患者72例,慢性肾功能不全患者61例以及肝硬化合并肝肾综合征患者18例.血浆Hcy检测用高效液相色谱法.结果与对照组相比,肝硬化组、慢性肾功能不全组以及肝肾综合征组的血浆Hcy浓度均显著升高;肝肾综合征组血浆Hcy浓度显著高于肝硬化组或慢性肾功能不全组(P<0.01).结论肝脏和肾脏在Hcy的清除中均起重要作用,肝脏和肾脏功能受损均可造成血浆Hcy水平升高.Objective To study the role of liver and kidney in catabolism of homocysteine （Hcy）. Methods 55 healthy volunteers, 72 patients with hepatic cirrhosis, 61 patients with chronic renal failure and 18 patients with hepatic cirrhosis as well as hepatorenal syndrome were included in this study. The concentration of plasma Hcy was determined by using high - pressure liquid chromatography. Results The levels of plasma Hcy in patients with hepatic cirrhosis, chronic renal failure and hepatorenal syndrome markedly increased, compared with that of the control group. The concentration of plasma Hcy in patients with hepatorenal syndrome was significantly higher than those in patients with either hepatic cirrhosis or chronic renal failure. Conclusion Insult in either hepatic or renal functions results in an increase in plasma Hcy. Thus, both liver and kidney play important roles in clearance of Hcy.

关 键 词：同型半胱氨酸 肝硬化 慢性肾功能不全 肝肾综合征 

分 类 号：R589.3[医药卫生—内分泌]