不孕患者卵巢功能早衰病因分析  

Etiological analysis of infertility women with premature ovarian failure

作　　者：石玉华[1] 陈子江[1] 张鹏[1] 盛燕[1] 高芹[1] 

机构地区：[1]山东大学省立医院生殖医学中心,济南250021

出　　处：《现代妇产科进展》2007年第3期199-201,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨不孕症患者卵巢功能早衰(POF)的病因特点。方法:回顾分析符合卵巢功能早衰诊断标准的不孕症121例的病因,其中有染色体结果者45例,对其进行详细分析。结果:(1)121例不孕的卵巢功能早衰患者中,有明确发病原因者14例(11.57%),其中行卵巢手术2例,服用卵巢毒性药物或有毒物接触史3例,染色体核型异常9例;(2)原发闭经6例,继发闭经115例,原发不孕95例(78.51%),继发不孕26例(21.49%),父母系近亲结婚3例。结论:卵巢功能早衰病因中染色体异常比例较高,对卵巢功能早衰患者行染色体检查很有必要;对不孕的POF患者开展遗传学研究具有重要的意义。Objective：To explore the etiology of premature ovarian failure （POF） in infertility. Methods：One hundred and twenty one infertility cases with POF were retrospectively analyzed. There were 45 cases whose chromosome were examined. Results： （ 1 ） Fourteen POF patients had specific reasons ：2 had ovarian operation;3 had taken toxico-ovary medicines and there were 9 cases with abnormal karyotype ; （2） Among the POF patients, there were 6 primary amenorrhea, 115 secondary amenorrhea ;95 primary infertility （78.51% ） ,26 secondary infertility （21.49%）. Meanwhile, there were 3 patients whose parents were intermarried. Conclusions：It is necessary to examine the karyotype of POF;Genetic research on POF patients with infertility is very important.

关 键 词：不育 女性 卵巢功能早衰 闭经 高促性腺激素 遗传 

分 类 号：R711.5[医药卫生—妇产科学]