瘦素抵抗和基因多态性与2型糖尿病的关系  

Relationship between type 2 diabetes and leptin resistance and its gene polymorphisms

作　　者：刘海玲[1] 谭渊明[1] 刘昭前[1] 

机构地区：[1]中南大学临床药理研究所

出　　处：《中国临床药理学与治疗学》2007年第3期262-265,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(30572230);教育部新世纪优秀人才支持计划(NCET-04-0749)

摘　　要：瘦素具有抑制胰岛素的分泌和表达、拮抗胰岛β细胞的调亡、调节骨骼肌和肝细胞糖代谢的重要病理生理功能。本文将对人体内瘦素抵抗现象和瘦素基因多态性与2型糖尿病的相关性以及它们对2型糖尿病药物治疗的影响作一综述。Leptin has many important pathophysiological effects, such as inhibiting insulin secretion and expression, constraining pancreatic β cell apoptosis and controlling glucose metabolism through skeletal muscle cell and hepatic cell. This review summarizes the phenomena of leptin resistance and leptin gene polymorphismin vivo, particularly emphasizing its correlation with type 2 diabetes and drugs clinical effective.

关 键 词：瘦素 瘦素抵抗 基因多态性 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]