ACE基因插入/缺失多态性与银屑病关系的研究  

Study on the Relationship between Insertion/deletion Ploylmorphism of Angiotensin-converting Enzyme Gene and Psoriasis

作　　者：刘晓红[1] 赵书平[1] 赵子卿[1] 赵荻 宋来涛[1] 杨惠[1] 

机构地区：[1]解放军88医院皮肤科,山东泰安271000

出　　处：《中国皮肤性病学杂志》2007年第4期199-200,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨血管紧张素转换酶(ACE)基因插入/缺失多态性与中国人群银屑病之间的关系。方法应用聚合酶链反应(PCR)对泰安地区88例银屑病患者及95例正常对照者的ACE基因插入/缺失多态性进行检测和分析。结果银屑病患者与正常对照者的II,ID,DD基因型及等位基因分布频率均无显著性差异(P>0.05),进一步分析显示ACE插入/缺失基因多态性与银屑病患者的性别及有无明确的家族史均无关联。结论ACE基因插入/缺失多态性可能不是中国人群银屑病发病的遗传学危险因素。Objective To investigate the relationship between insertion/deletion （I/D） ploylmorphism of the angiotensin - converting enzyme（ACE） gene and psoriasis in Chinese population. Methods A group of 88 patients with psoriasis and 95 control subjects were analysed for ACE I/D ploylmorphism by polymerase chain reaction in Taian region. Results The distribution of ACE I/D ploylmorphism and allele frequencies in psoriasis patients was not significantly different from that of controls（ P 〉0.05 ）. Futher analyses of psoriasis patients showed that ACE I/D ploylmorphism was not associated with gender and family history of psoriasis. Conclusion I/D ploylmorphism of ACE gene may not be a genetic risk of psoriasis in Chinese population.

关 键 词：银屑病 血管紧张素转换酶(ACE) 基因 多态性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]