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作 者:王淑芳[1] 李冰[1] 薛秀美[1] 王坤[1] 陈建勇[1] 王媛
机构地区:[1]胶南市人民医院,山东省胶南266400 [2]青岛市开发区卫生监督所
出 处:《中华航海医学与高气压医学杂志》2007年第2期101-103,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine
摘 要:目的研究高压氧治疗脑挫裂伤前后患者免疫功能的变化。方法采用免疫速率散射比浊法检测114例脑挫裂伤患者治疗前后血浆中C_3、C_4、IgG、IgA、IgM的变化,采用GCS评分标准判断疗效。结果GCS评分:高压氧治疗组(12.95±1.96)分,对照组(9.67±2.82)分,两组比较差异有统计学意义(P<0.01)。补体水平:高压氧组治疗前C_3、C_4分别为(0.97±0.28)g/L和(0.31±0.27)g/L;治疗后C_3、C_4分别为(1.20±0.23)g/L和(0.43±0.27)g/L;治疗前后结果比较差异有统计学意义(P<0.01),与对照组比较差异无统计学意义(P>0.05)。免疫球蛋白水平:高压氧治疗前IgG(10.47±2.89)g/L,治疗后(9.83±3.2)g/L,治疗前后比较差异有统计学意义(P<0.05);IgA治疗前(1.45±0.65)g/L,治疗后(1.53±0.84)g/L,治疗前后比较差异无统计学意义(P>0.05);IgM治疗前(2.04±0.87)g/L,治疗后(1.86±0.94)g/L,治疗前后比较差异有统计学意义(P<0.01)。结论高压氧治疗脑挫裂伤能明显增强机体的免疫机能。Objective To study changes of immune function in patients with cerebral contusion and laceration before and after hyperbaric oxygen (HBO) therapy. Methods Among 114 cases with cerebral contusion and laceration,84 cases were treated with HBO, and 30 cases were treated with regular methods. C3 , C4, IgG, IgA, IgM levels were measured with rate nepherometry before and after HBO treatment. Results Glasgow coma scale(GCS) score was ( 12.95 ± 1.96 ) after treatment in the HBO group, which was significantly different from (9.67 ± 2.82) in the control group( P 〈 0.05 ) ; the values of C3, C4 before HBO was (0.97 ± 0. 28)g/L and(0.31 ± 0.27 ) g/L, which were significantly different from ( 1.20 ± 0.23 ) g/L and (0.43 ± 0. 27 )g/L after HBO treatment( P 〈0. 01 ). The value of IgG, before HBO treatment was ( 10.47 ±2.89 )g/L, which was significantly different from ( 9.83 ± 3.2 ) g/L after HBO treatment ( P 〈 0.05 ) ; the value of IgA before treatment was ( 1.45 ±0.65 ) g/L, which was not significantly different from ( 1.53 ± 0.84 ) g/L after treatment (P 〈 0.05 ) ; the value of IgM before treatment was ( 2.04 ± 0.87 ) g/L, which was significantly different from ( 1.86 ± 0.94 ) g/L after treatment ( P 〈 0.01 ). Conclusions The immune function of the cerebral contusion and laceration patients can be improved by HBO treatment.
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