血浆脂联素与2型糖尿病及其大血管病变相关性研究  

The role and relationship of plasma adiponectin in the type 2 diabetes mellitus patients and macrovascular artherosclerosis.

作　　者：张新焕[1] 黄东辉[1] 程厚文[1] 王焕云[1] 宋晓[1] 

机构地区：[1]泰山医学院附属医院内分泌科,山东泰安271000

出　　处：《泰山医学院学报》2006年第5期428-430,共3页Journal of Taishan Medical College

摘　　要：目的探讨血浆脂联素(ad iponectin)在2型糖尿病及糖尿病大血管病变中的作用及相关性。方法2型糖尿病(T2DM)患者68例,分为单纯糖尿病组及糖尿病下肢血管病变组,对照组30例。对所有研究对象常规行空腹血糖(FPG)、血总胆固醇(TC)、甘油三酯(TG)、糖化血红蛋白(HbA1c)和空腹胰岛素(FINS)水平测定,并计算体重指数(BM I)及胰岛素敏感指数(ISI);采用ELISA法测定各标本血浆脂联素水平,并对各组间临床指标进行比较,对各指标与脂联素水平的相关性进行相关和回归分析。结果与对照组比较,2型糖尿病患者FPG、TC、TG和FINS、BM I、HbA1c水平明显高于对照组(P<0.05或P<0.01),血浆脂联素水平及ISI糖尿病合并大血管病变组明显低于单纯糖尿病组和对照组(P<0.01)。且血浆脂联素水平糖尿病下肢血管病变组也明显低于单纯糖尿病组(P<0.01);2型糖尿病病人血浆脂联素水平与下肢血管病变、FPG、TC、TG、BM I及HbA1 c显著负相关,与ISI呈显著正相关。结论:血浆脂联素在2型糖尿病及糖尿病大血管病变的发生中可能发挥保护性作用,血浆脂联素水平降低可能是发生糖尿病及糖尿病大血管病变的一个独立危险因素。Objective ：To explore the role of plasma adiponectin in the type 2 diabetes meUitus patients and macrovascular artherosclerosis. Methods：In a cross sectional study, All subjects randomly recruited in were divided into group one（ type 2 diabetes with artherosclerosis ）, group two （ type 2 diabetes without artherosclerosis ） and normal control group. We measured adiponectin through ELISA, The parameters of fasting plasma glucose （FPG）, total cholesterol （TC） and triglyceride （TG）, fasting insulin level in plasma （FINS） and glycosylated hemoglobin（ HbA1c） were measured, Insulin sensitive index （ISI） and body mass index （BMI）were calculated, All calculations were performed using the SPSS 10.0 version for Windows. Results：Compared the clinical index among the three groups, the level of FPG, TC, TG, FINS, HbA1c and BMI in type 2 diabetes mellitus patients were significantly higher （ P 〈 0. 01 ） and the concentration of plasma adiponeetin and the level of ISI were significantly lower （ P 〈 0.01） than in the controls, and the concentration of plasma adiponeetin is much lower in the group of type 2 diabetes with artheroselerosis than in group of type 2 diabetes without artherosclerosis, the level of plasma adiponectin was correlated positively with ISI （ P 〈 0. 01 ） and negatively with FPG, TC, TG, age,HbA1c,BMI and macrovascular artherosclerosis （ P 〈 0. 05 ）.

关 键 词：2型糖尿病 脂联素 糖尿病大血管病变 

分 类 号：R587.2[医药卫生—内分泌]