射频热疗与α_(1A)受体阻滞药物治疗前列腺增生症临床随访报告  

The clinical report of the follow-up of radiofrequency thermotherapy and α_(1A) adrenoceptor antagonist for the treatment of benign prostatic hyperplasia

作　　者：周玉海[1] 张晶[2] 綦岩[1] 高保华[1] 程川[1] 郑立泉[1] 

机构地区：[1]泰山医学院附属医院泌尿外科,山东泰安271000 [2]泰安市中心医院外一科,山东泰安271000

出　　处：《泰山医学院学报》2006年第5期443-445,共3页Journal of Taishan Medical College

摘　　要：目的比较α1A肾上腺素能受体阻滞类药物盐酸坦索罗辛与射频热疗治疗前列腺增生症的临床效果。方法门诊随机选择前列腺增生症病人60例并随机分成两组各30例,分别采用体外射频热疗和口服α1A肾上腺素能受体阻滞剂盐酸坦索罗辛治疗,随访3个月,对照两组国际前列腺症状评分(IPSS)及尿流率的改善程度,并随访并发症的发生情况。结果两组病人对热疗和α1A受体阻滞药物的治疗均有肯定的疗效,与治疗前对照症状及尿流率显著改善;盐酸坦索罗辛的IPSS改善优于热疗组,尿流率的改善程度两组相似,差别无统计学意义;两组病人并发症均较轻,多为一过性,并未影响治疗。盐酸坦索罗辛组的并发症常见有口干、鼻塞等,无直立性低血压发生,发生率6.7%;热疗组的并发症常见有皮肤灼伤、脂肪硬化、睾丸痛等,发生率13.8%,两组病人的并发症发生率比较无显著意义。结论α1A受体阻滞类药物和射频热疗可明显改善前列腺增生症症状评分,且并发症发生率低,无严重的并发症发生。对症状较轻,无绝对手术指征的前列腺增生症患者以及年龄较大和重要脏器功能不能耐受手术的患者,提供了安全而具有较好效果的治疗方法。Objective To compare the effects of α1A adrenoceptor antagonist tamsolusin and extra -radiofrequency thermotherapy （ ERTH ） for benign prostatic hyperplasia （ BPH ）. Methods 60 BPH eases were randomly selected and divided into 2 groups in out patient department and there were 30 patients in each group. Two theropeutic methods were applied to them respectively and there was a 3 - month followup. The improvement of the international prostatic symptom score （ IPSS ） and urinfollowmetry rate pre - and post - therapy were compared , and a comparison of the therapeutic effects and the complications after treatment between the two therapeutic methods was made. Results The two methods had the positive effects on BPH patients, the IPSS and urinefollow - merry rate were improved obviously in the two groups, and the curative effects of tamsolusin was much better than ERTH in the improvement of IPSS, hut the urinefollow rate improvement in the two grpups was not significantly different. The complications in the two groups were all slight and short, and the treatment were not influnced by them. And the rate of the occurrance of the complications in the two groups was not significantly different. Conclusion α1A adrenoceptor blockers and ERTH have marked effects on BPH as theroprutie methods, and they can improve the IPSS and urinefollow rate with low morbidity of complications. So they are two effective methods for the patients with minimal symptoms and the patients who are older or who have contraindications to surgical operation due to the dysfunction of the vital organs.

关 键 词：体外射频 热疗 α1A受体阻滞药物 前列腺增生症 

分 类 号：R697.3[医药卫生—泌尿科学]