高锰酸钾-鲁米诺化学发光体系分子印迹-后化学发光法测定奋乃静  

Molecular Imprinting-Post Chemiluminescence Method for the Determination of Perphenazine in Potassium Permanganate-Luminol System

作　　者：牛卫芬[1] 吕九如[1] 

机构地区：[1]陕西师范大学化学与材料科学学院

出　　处：《分析化学》2007年第2期281-284,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No.20275023);陕西省自然科学基金(No.2002B12)资助项目

摘　　要：结合分子印迹技术,建立了测定奋乃静的分子印迹-后化学发光(MI-PCL)分析方法。方法的线性范围为1.0×10-4-1.0×10-2g/L,线性相关系数为0.9984;相对标准偏差为4.3%(Cs=1.0×10-3g/L,n=11);方法的检出限为3×10-5g/L。本法应用于尿样中奋乃静含量的测定,结果令人满意。A post chemiluminescence （PCL） phenomenon was observed when perphenazine was injected into the reaction mixture after the finish of chemiluminescence （CL） reaction of potassium permanganate with luminol. A perphenazine molecular imprinted polymer （MIP） was synthesized. Using the perphenazine MIP as the recognition material, a novel molecular imprinting-post chemiluminescence （MI-PCL） method for the determination of perphenazine was established. The linear range of the method were 1.0 × 10^-4 - 1.0 × 10^ -2 g/L with a linear correlation coefficient of 0. 9984. The detection limit was 3 × 10^ -5 g/L and the relative standard deviation for 1.0 × 10^-3 g/L perphenazine solution was 4.3% （n = 11 ）. The method has been applied to the determination of perphenazine in urine sample with satisfactory results.

关 键 词：分子印迹聚合物 化学发光 奋乃静 

分 类 号：R927[医药卫生—药学]