六味地黄软胶囊和银杏叶片对2型糖尿病患者血清RANTES水平的影响  

Effect of Liuwei Dihuang Soft Capsule and Ginkgo Leaf Tablet on Serum Regulated upon Activation,Normal T Cell Expressed and Secreted in Patients with Diabetes Mellitus Type 2

作　　者：王祥香[1] 孙子林[1] 余江毅[2] 杨兵全[1] 王尧[1] 

机构地区：[1]东南大学附属中大医院内分泌科,南京210009 [2]江苏省中医院内分泌科

出　　处：《中国中西医结合杂志》2007年第4期315-317,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江苏省科技厅科技示范工程招标项目(NoBS2003056)

摘　　要：目的探讨中药六味地黄软胶囊和银杏叶片对2型糖尿病患者血清受活化调节、由正常T细胞表达和分泌的趋化蛋白(regulated upon activation,normal T-cell expressed and secreted,RANTES)水平的影响。方法在西药降糖治疗基础上,40例早期2型糖尿病患者,随机分为中药组和安慰剂组,每组20例,分别给予六味地黄软胶囊及银杏叶片或安慰剂治疗6个月,检测治疗前后血清RANTES、血糖、血脂、糖化血红蛋白及尿微量白蛋白水平。结果中药组治疗后血清RANTES较治疗前明显下降,且明显低于安慰剂组(P<0.05)。结论六味地黄软胶囊及银杏叶片可降低2型糖尿病患者血清RANTES水平,可能通过抗炎机制防治糖尿病并发症。Objective To investigate the effect of Liuwei Dihuang Soft Capsule（LDSC） and Ginkgo Leaf Tablet （GLT） on serum regulated upon activation, normal T cell expressed and secreted （RANTES） in the patients with diabetes mellitus type 2 （DM2）. Methods signed to two groups, 20 in each group. Based on the Forty patients with early stage DM2 were randomly asconventional treatment with hypoglycemic agents, patients in the treated group were treated with LDSC plus GLT additionally, and those in the placebo group with placebo for 6 months, respectively. The levels of serum RANTES, blood glucose, blood lipids and glycosylated hemoglobin, as well as micro-content of albumin in urine were measured before and after treatment. Results In the treated group, the serum level of RANTES decreased significantly after treatment, and it was significantly lower as compared with that in the control group （P 〈0.05）. Conclusions LDSC and GLT can decrease serum RANTES level in patients with DM2. They play a preventive and therapeutic role on diabetic complications by their anti-inflammatory effect.

关 键 词：六味地黄软胶囊 银杏叶片 糖尿病 受活化调节 由正常T细胞表达和分泌的趋化蛋白 

分 类 号：R259[医药卫生—中西医结合]