三个监测点医院2001—2004年婴幼儿轮状病毒腹泻监测  

Rotavirus diarrhea among children in three hospitals under sentinel surveillance, from August 2001 to July 2004

作　　者：张丽杰[1,10] 方肇寅[1] 孙利炜[2] 杜曾庆[3] 唐景裕 曾光[5] Duncan Steele Paul Kilgore Xi Jiang Roger Glass 江保明 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所腹泻室,北京100052 [2]长春市儿童医院 [3]昆明市儿童医院 [4]河北省卢龙县疾病预防控制中心 [5]中国疾病预防控制中心 [6]Would Health Organization [7]International Vaccine Institute [8]Cincinnati Children＇ s Hospital Medical Center, USA [9]Centers for Disease Control and Prevention, USA [10]中国疾病预防控制中心中国现场流行病学培训项目,北京100050

出　　处：《中华流行病学杂志》2007年第5期473-476,共4页Chinese Journal of Epidemiology

基　　金：美国适宜卫生科技组织基金资助项目（PATH,GAV.1142-01-07228-LPS）;世界卫生组织基金资助项目（V27/181/123）

摘　　要：目的 了解3个监测点医院2001年8月至2004年7月住院的5岁以下婴幼儿轮状病毒腹泻流行状况。方法 以医院为基础的哨点监测,监测对象为5岁以下腹泻住院患儿。收集患儿的临床资料和粪便标本并进行轮状病毒检测和分型。结果 共检测3121份腹泻患儿的粪便标本,轮状病毒检出率为51%。94%的轮状病毒腹泻发生在2岁以下儿童。G3型为流行优势株,占69．9%,其次为G1型6．6%、G2型2．9%、G9型2．2%、G4型0．3%。P[8]型为最常见的P基因型。最常见的P-G组合型是P[8]G3,占64．0%,还有其他7种不常见的P-G组合的毒株类型。结论 轮状病毒是3个监测点医院住院腹泻患儿的主要病原,P[8]G3型为主要流行株。Objective To learn the epidemiologic characteristics of rotavirus diarrhea in three hospitals under sentinel surveillance from August 2001 to July 2004 and to provide background information for developing and implementing rotavirus vaccine. Methods Data from hospital-based rotavirus surveillance among children 〈 5 years old hospitalized with acute diarrhea was used. Patients＇ clinic information and feces specimens were collected. Specimens were tested and typed for rotavirus. Results Totally, 312l specimens were tested and the detection rate of rotavirus was 51%. Among all the children with rotavirus diarrhea,94 % were 〈 2 years old. G3（69.9 % ） was the most prevalent serotype followed by Gl（6.6 % ） and G2 （2.9 % ）. P[ 8] was the most common genotype of rotavirus. The most common G-P combination identified in this study was P[ 8 ] G3 （64.0 % ）. Seveal other combinations of minor frequency were also identified. Conclusion Rotavirus infection was most commonly seen among children 〈 5 years old hospitalized with acute diarrhea in the three hospitals. It is important to develop and implement rotavirus vaccine to prevent and control severe rotavirus infection. Because of the diversity of rotavirus strains, it is necessary to perform rotavirus strain surveillance to understand the dynamic nature of viral transmission.

关 键 词：轮状病毒 腹泻 监测 

分 类 号：R686[医药卫生—骨科学]