2%含量的过氧乙酸吸入刺激实验  

Respiratory Irritation Caused by Inhalation of 2% Peracetic Acid Aerosol

作　　者：张大维[1] 邴国强[2] 徐彩云[1] 李萍[2] 杨东华[3] 于艳波[3] 刘占军[4] 郭超 

机构地区：[1]吉林大学基础医学院动物实验中心,吉林长春130021 [2]吉林大学体育学院实验中心,吉林长春130012 [3]吉林大学第二临床医学院实验动物观察室 [4]长春生物制品研究所实验动物室 [5]长春精优药业股份有限公司

出　　处：《中国比较医学杂志》2007年第4期223-224,共2页Chinese Journal of Comparative Medicine

基　　金：吉林省科技发展计划项目(项目编号吉科合字第20000200号)

摘　　要：目的观察2%含量的过氧乙酸溶液喷雾消毒时,对工作人员和实验动物的刺激性。方法利用隔离器,观察2%含量的过氧乙酸溶液喷雾消毒,达到1 g/m3浓度,维持30 min,观察对大鼠肺脏的损伤。结果利用2%含量的过氧乙酸对大鼠进行吸入性实验,致使大鼠肺部均出现不同程度的组织病理变化。结论2%过氧乙酸溶液在对运行中的实验动物屏障环境进行喷雾消毒,对实验动物及工作人员呼吸系统有刺激性损伤。Objective the purpose of this study is to determine if inhalation of 2% peracetic acid aerosol is harmful to humans and laboratosy animals. Methods Rats were kept in an isolator containing 2% peracetic acid aerosol in a concentration of 1g/m^3 for 30 minutes. Pulmonary alterations in the rats were assessed by pathological examination. Results Pathological changes in the rat lungs to a varying degree were caused by this procedure. Conclusions Disinfection under the barrier environment with 2% peracetic acid aerosolis irritative and harmful to laboratory workers and animals.

关 键 词：过乙酸 消毒 刺激 肺 大鼠 

分 类 号：R33[医药卫生—人体生理学]