枸橼酸氢钾钠降低草酸钙结石成石危险性的机制  

The efficacy of potassium sodium hydrogen citrate intervention on urinary risk factors for calcium renal stone formation

作　　者：代海涛[1] 陈志强[1] 叶章群[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,武汉430030

出　　处：《临床泌尿外科杂志》2007年第4期287-288,291,共3页Journal of Clinical Urology

摘　　要：目的:探讨枸橼酸氢钾钠降低草酸钙结石成石危险性的机制。方法:经B超、X线、尿生化检查诊断为肾或输尿管含钙结石18例,其中肾结石16例,输尿管结石2例。测定口服枸橼酸氢钾钠前后尿生化参数进行比较。结果:口服枸橼酸氢钾钠2周时,尿pH值、枸橼酸、(可溶解钙×枸橼酸)/(总钙×草酸)明显升高,尿钙降低,与服用前比较,差异均有统计学意义(P<0.05)。24h尿中尿酸、草酸变化无统计学意义。结论:枸橼酸氢钾钠可有效降低含钙结石成石危险性。Objective：To investigate the mechanism of potassium sodium hydrogen citrate inhibiting the formation of calcium stone. Methods：A total of 18 cases of 9 men and 9 women calcium stone formers were studied, 16 with renal stones and 2 with ureteral stones. All cases were identified by ultrasound, plain film of kidney-ureter bladder and urine biochemical examination. Collected 24 hour urine on their habitual, and after 2 weeks on potassium sodium hydrogen citrate. Results： Urine pH, 24-hour citrate excretion, the value （iCa^2＋×Cit）/（ TCa^2-Ox） increased; 24-hour calcium excretion with the difference being significant （ P 〈0.05） after 2 weeks treatment. But the change of 24-hour uric acid excretion, 24-hour oxalic acid excretion are insignificant （ P 〉0.05）. Conclusions：Taking potassium sodium hydrogen citrate could inhibit the formation of calcium stone effectively.

关 键 词：尿结石 枸橼酸氢钾钠 成石危险性 

分 类 号：R691.4[医药卫生—泌尿科学]