乙型肝炎病毒基因型及其临床意义的研究进展  

Advances in the researches on hepatitis B virus genotyping and its clinical significance

作　　者：游晶[1] 庄林[2] 陈红英[3] 杨海秋[3] 唐宝璋[3] 黄梦玲[3] 

机构地区：[1]昆明医学院第一附属医院感染病科,云南省昆明市650032 [2]昆明市第三人民医院肝病科,云南省昆明市650041 [3]昆明医学院第一附属医院感染痛科,云南省昆明市650032

出　　处：《世界华人消化杂志》2007年第9期921-928,共8页World Chinese Journal of Digestology

摘　　要：乙型肝炎病毒(HBV)基因型的研究是目前乙型肝炎国内外研究的热点.HBV基因分型比血清亚型更能准确地反映原型病毒株之间的自然异质性,HBV基因分型方法有多种,以全基因测序为HBV基因分型的金标准,基于全基因核苷酸序列比较,HBV可分为A,B,C,D,E,F,G,H 8个基因型.HBV基因型呈地理区域性分布,且不同基因型致病性不同,HBV基因型与乙型肝炎病情的进展、临床表现、治疗、预后有密切的关系.本文就近几年HBV基因型及其临床意义的研究进展作一综述.The genotyping of hepatitis B virus （HBV） is a highlight of the studies associated with chronic hepatitis B inside and outside the country nowadays. HBV infection can lead to chronic carriage of the virus and progressive liver disease, including liver cirrhosis and hepatocellular carcinoma. The serological heterogeneity of HBsAg has been well established. HBV isolates have been classified into 10 different subtypes according to the antigenic determinants of their HBsAg. However, the classification of HBV by serologic subtyping is not rational because a single point mutation at the S gene may result in a change in subtype. Therefore, worldwide HBV isolates have been classified into eight genotypes： A, B, C, D, E, F, G and H, based on the comparison of complete HBV genomes, which is the gold standard for genotyping. The eight genotypes have a distinct characteristic geographical distribution and an HBV genotypic difference in HBV pathogenicity. It has been reported that there are remarkable differences in the clinical and virologic characteristics between the patients with different genotypes. Studies have revealed the association of HBV genotypes with the severity and outcome of chronic liver disease, but the results including the influence of genotypes on therapeutic responses are not consistent.

关 键 词：乙型肝炎病毒 基因分型 变异 临床意义 

分 类 号：R512.62[医药卫生—内科学]