单纯疱疹Ⅰ型病毒载体与慢性疼痛转基因治疗的研究进展  

Development of HSV- I based vector mediated gene transfer for the treatment of chronic pain

作　　者：邹望远[1] 郭曲练[1] 

机构地区：[1]长沙市中南大学湘雅医院麻醉科,410008

出　　处：《实用疼痛学杂志》2007年第2期148-152,共5页Pain Clinic Journal

基　　金：国家自然科学基金课题资助(30271256)

摘　　要：慢性疼痛是一个巨大的医疗难题,目前传统的治疗方法都存在一定局限性,单纯疱疹病毒Ⅰ型载体具有天然嗜神经性,适合神经系统转基因治疗。现就单纯疱疹病毒Ⅰ型载体及其转前脑啡肽原基因在炎性疼痛、神经病理性疼痛、癌性疼痛中的应用作一综述。Treatment of chronic pain is extremely difficult. Current traditional treatments may be limited with regard to analgesic efficacy or side effects. Neurotropic herpes simplex virus type Ⅰ （ HSV- Ⅰ ） based vector is suit for gene transfer applications in the nervous system. The developments of HSV-Ⅰ-based vectors expressing proenkephalin in rodent models of imflammatory pain, neuropathic pain and pain resulting from cancer in bone were reviewed.

关 键 词：单纯疱疹病毒 Ⅰ型 载体 慢性病 疼痛 基因 治疗 脑啡肽类 

分 类 号：R346[医药卫生—基础医学]