慢性阻塞性肺疾病急性加重期呼出气冷凝液中的标记物及其意义  

Biomarkers and their significance in exhaled breath condensate of acute exacerbations of chronic obstructive pulmonary disease

作　　者：高蕾[1] 周新[1] 

机构地区：[1]上海交通大学附属第一人民医院,200080

出　　处：《国际呼吸杂志》2007年第9期696-699,共4页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病（COPD）急性加重期存在着炎症反应和氧化应激反应,这些变化可通过对呼出气冷凝液中生物学标记物的检测得知。呼出气冷凝液是一种可重复的无创检测手段,目前可用于检测的主要标记物有过氧化氢、花生四烯酸衍生物、脂质过氧化产物、一氧化氮衍生物及细胞因子等。本文主要介绍上述各标记物在COPD急性加重期的临床意义。It is accepted that acute exacerbations （AE） are the inflammatory phases of chronic obstructive pulmonary disease （COPD）. There is also evidence of increased oxidative stress during exacerbations. Airway inflammation and the oxidative stress can be measured using exhaled breath condensate（EBC）, which is completely noninvasive and can be undertaken repeatedly in the same individual. So far, the biomarkers in the EBC during AECOPD include H2O2, eicosanoids, products of lipid peroxidation, NO-related products and cytokines, This review mainly introduces these biomarkers and their significances during AECOPD.

关 键 词：慢性阻塞性肺疾病 急性加重期 呼出气冷凝液 生物学标记物 

分 类 号：R563[医药卫生—呼吸系统]