抗抑郁药物及其研究方法的进展  

Advances in antidepressants and research methods of depression

作　　者：杨小莹[1] 陈杰 杨新明 马世平[1] 

机构地区：[1]中国药科大学中药药理教研室,江苏南京210038 [2]广东彼迪药业有限公司质量部,广东开平529331

出　　处：《中国中药杂志》2007年第9期770-774,共5页China Journal of Chinese Materia Medica

基　　金：江苏省自然科学基金项目(BK2005149);江苏省中医药局中医药科研项目(H05074);江苏省教育厅自然科学基金项目(02KJB360002)

摘　　要：抑郁症的防治已引起世界范围内的重视。通过查阅国内外近年来有关文献结合相关的研究成果,对抗抑郁药物,尤其是天然药物的提取物、活性成分及中药复方的研究进展进行了分类综述;并就药物研究所采用的实验方法(动物模型)的进展情况作了总结,将实验研究方法与临床实际相结合,对其一致性、不足之处、临床价值等方面进行了分析讨论。Depression, a mental illness marked by feeling of extreme sadness, hopeless and inadequately, has been attached much importance. In this review, we summarized the research development of antidepressants, especially the active constituents, the extracts and the compound Chinese medicine of nature medicine, through consulting the relevant papers; and animal models of depres- sion, have been utilized to screen novel drugs with antidepressant, were compared with clinical efficacy to evaluate the concordance, weak links and clinical values. Although animal models of depression fail to be unequivocally valid, also depression models generally lack both clinical and scientific credibility, they represent the tool to define potential antidepressant activity of drugs by far. Animal modeling remains a potentially important approach towards understanding neurobiological mechanisms in depression.

关 键 词：抑郁症 天然药物 动物模型 临床效应 

分 类 号：R971[医药卫生—药品]