冠心苏合丸系列组方对犬心脏血流动力学及心肌耗氧量的影响  

Effects of series of Muskone on heart hemodynamics and myocardial consumption of oxygen in experimental dogs

作　　者：张永涛[1] 马堃[1] 张金艳[1] 李贻奎[1] 吴理茂[2] 李向日[3] 潘理[4] 高会丽[1] 李连达[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]浙江大学药学院,浙江杭州310031 [3]北京同仁堂股份有限公司科学研究所,北京100011 [4]沈阳中药制药有限公司,辽宁沈阳110044

出　　处：《中国中药杂志》2007年第9期827-830,共4页China Journal of Chinese Materia Medica

基　　金：国家"十五"科技攻关重点项目(2004BA721A10)

摘　　要：目的:通过观察冠心苏合丸系列组方对心脏血流动力学及心肌耗氧量的影响,阐述其对心血管系统的作用。方法:观测冠心苏合丸系列组方对正常麻醉犬动脉血压、冠脉流量、冠脉阻力和总外周阻力、左室做功以及心肌耗氧指数、心肌氧利用率的影响。结果:冠心苏合丸系列组方可明显降低动脉血压,扩张冠脉血管及外周血管,增加冠脉流量,降低冠脉阻力;改善左室做功和心肌氧利用率,调整心脏血管的顺应性。结论:对心血管系统起到调整和改善作用。Objective：To observe the effects of series of Muskone （the muskone includes Slender Dutchmanspipe Root, Inula Root and neither kind of Common Aucklandia Root ） on the heart hemodynamics and myocardial consumption of oxygen in experimental dogs, and to explain its pharmacological action on cardiovascular system. Method： Arterial blood pressure, coronary blood flow, resistance in coronary artery, total peripheral resistance, work of left artrium and oxygen consumption index of the cardiac muscles were observed in anaesthetic dogs. Result： The series of Muskone decreased arterial blood pressure significantly, dilated coronary artery and peripheral arteries significantly, increased coronary blood flow, decreased resistance in coronary artery, improved the work of left artrium, the oxygen availability of cardiac muscles and the complaisance of arteries in cardiac muscles.

关 键 词：冠心苏合丸系列方 比较药理学 马兜铃酸 青木香 土木香 

分 类 号：R285.5[医药卫生—中药学]