心脉通胶囊对急性冠脉综合征患者血清MMP-9与高敏CRP影响的临床观察  

Effect of Xinmaitong capsule on serum matrix metalloproteinases-9,high sensitive C-reactive protein levels in patients with acute coronary syndrome

作　　者：孟君[1] 秦鉴[1] 马芸[2] 孙慧兰[2] 罗初凡[1] 丘瑞香[1] 

机构地区：[1]中山大学附属第一医院,广东广州510058 [2]中山大学中山医学院,广东广州510080

出　　处：《中国中药杂志》2007年第9期850-852,共3页China Journal of Chinese Materia Medica

基　　金：广东省医药管理局科研基金资助项目(1050173)

摘　　要：目的:探讨心脉通胶囊对急性冠脉综合征(ACS)患者抑制细胞外基质降解,减少炎症反应,稳定斑块的作用。方法:采用随机对照方法将ACS患者分为治疗组(对照组基础上加用心脉通胶囊n=31)、对照组(n=32),于治疗前后分别测定血清MMP-9与hs-CRP水平。结果:对照组MMP-9较治疗前有所下降但无统计学意义,而hs-CRP水平治疗后有显著性下降。治疗组MMP-9与hs-CRP水平均较治疗前明显改善,并明显优于对照组(P<0.05)。ACS患者MMP-9与hs-CRP水平呈正相关,而MMP-9,hs-CRP与血脂无相关。结论:心脉通胶囊可能通过抑制MMP-9,降低hs-CRP,而减少细胞外基质降解,减轻炎症反应达到稳定斑块的作用。Objective： To observe the influence of Xinmaitong capsule （XMT） on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome. Method： 63 cases were divided by randomized, contrastire assigned to XMT group （n =31） and control group （n=32）. The serum levels of MMP-9 and hs-CRP before and after treatment in 12 weeks were detected. Result： After treatment, the serum levels of MMP-9 in control group had no changed and the levels of hs- CRP reduced. The serum levels of MMP-9 and hs-CRP in XMT group had significantly decreased. The serum levels of MMP-9 and hs- CRP had positive correlation, but had no correlation to levels of serum lipids. Conclusion： XMT decreased breakdown of matrix collagen. and inflammatory reaction in the patients of ACS. which may have effect on plaque stabilization.

关 键 词：心脉通胶囊 急性冠脉综合征 基质金属蛋白酶-9 高敏C反应蛋白 

分 类 号：R259[医药卫生—中西医结合]