杂化改性后快速成型支架对骨缺损修复的实验研究  

Study of repairing of radius defects hybridized RP scaffold

作　　者：庞龙[1] 胡蕴玉[1] 颜永年[2] 刘利[2] 熊卓[2] 吕荣[1] 王军[1] 

机构地区：[1]第四军医大学西京医院骨科研究所,陕西西安710032 [2]北京清华大学机械工程系,北京100084

出　　处：《创伤外科杂志》2007年第3期257-260,共4页Journal of Traumatic Surgery

基　　金：军队"十五"重点课题资助项目(01Z079)

摘　　要：目的观察以PLGA/β-TCP为原材料,快速成型方法制备的支架为骨架,采用胶原杂化及表面磷灰石沉积对其进行改性的新型骨组织工程材料对骨缺损的修复效果。方法使用骨髓基质干细胞(BM-SCs)分别与改性前后支架复合,对兔桡骨缺损进行修复。通过X-ray、M icro CT形态学及组织切片病理学,观察改性前后材料降解、新骨生成情况。结果改性后材料的降解及骨缺损修复能力较改性前有显著性提高,修复1年后改性组骨缺损完全修复。结论采用胶原杂化及磷灰石表面沉积改性后的PLGA/β-TCP快速成型支架可作为3-D支架应用于骨组织工程。Objective To observe the effects of hybridized RP scaffold on repairing segmental bony defects. Methods BMSCs were seeded into the hybridized and original RP scaffold to repair 15 mm segmental defect in the radius of rabbits. Radiograph,the scaffold degrading rate and new bone formation were evaluated by Micro CT and histology. Results The results suggested that the apatite/collagcn sponge composite coating could improve the RP scaffold degrading rate and new bone forming in vivo. Bony union was observed in experimental group 1 year after the operaion. Conclusion The PLGA/β-TCP scaffold with apatite/collagen sponge composite coating is promising as a candidate 3-D substrate for bone tissue engineering.

关 键 词：桡骨缺损 创伤 修复 

分 类 号：R683.41[医药卫生—骨科学]