臭灵丹萜类和黄酮化合物(英文)  

Terpenoids and flavonoids from Laggera pterodonta

作　　者：杨光忠[1] 李芸芳[1] 喻昕[2] 梅之南[1] 

机构地区：[1]中南民族大学民族药物研究所,湖北武汉430074 [2]武汉大学药学院,湖北武汉430072

出　　处：《药学学报》2007年第5期511-515,共5页Acta Pharmaceutica Sinica

摘　　要：臭灵丹(Laggera pterodonta)为菊科四棱峰属植物,是云南民间抗菌消炎的良药。本文对臭灵丹地上部分的化学成分进行了研究。其地上部分用水煎煮提取,硅胶柱色谱和重结晶等方法进行分离纯化。从该植物中分离得到11个化合物,其结构分别鉴定为:6-O-β-D-glucopyranosyl-carvotanacetone(1),臭灵丹酸(2),1β-hydroxypterondontic acid(3),pterodontoside A(4),臭灵丹二醇(5),臭灵丹三醇乙(6),5-hydroxy-3,4′,6,7-tetramethoxyflavone(7),洋艾素(8),金腰素乙(9),槲皮素(10)和β-谷甾醇(11)。化合物1为新的单萜苷,化合物10和11为首次从该植物中发现。应用滤纸扩散法对该植物中的两个化合物2和5的抑菌活性进行检测,结果表明这两个化合物对金黄葡球菌、铜绿假单孢菌、枯草芽胞杆菌、草分支杆菌和环状芽胞杆菌均呈现明显的抑菌活性,但对大肠埃希氏菌均未呈现抑菌活性。To study the chemical constituents of aerial parts of Laggera pterodonta （ DC. ） Benth. , the air-dried aerial parts of this plant were powered and extracted with boiling water and purified by silica gel column chromatography and recrystallized. Eleven compounds were obtained from L. pterodonta. They were identified as to be 6-O-β-D-glucopyranosyl-carvotanacetone （ 1 ）, pterodontic acid （2）, β-hydroxy pterondontic acid （3）, pterodontoside A （4）, pterodondiol （5）, pterodontriol B （ 6）, 5-hydroxy-3,4＇, 6,7-tetramethoxyflavone （7） , artemitin （8）, chrysosplenetin B （9） , quercetin （10） and β-sitosterol （11）. Compound 1 is a new monoterpene glucoside. Compounds 10 and 11 were isolated from this plant for the first time. Compounds 2 and 5 showed moderate activity against bacteria including Staphylococcus aureus , Pseudomonas aeruginosa , Bacillus subtilis , Mycobacteium phlei and Bacillus circulans by paper disc diffusion method, while they both displayed no activity against Escherichia coli.

关 键 词：臭灵丹 单萜苷 萜类化合物 黄酮类化合物 抗菌活性 

分 类 号：R284.1[医药卫生—中药学]