TRP超家族与肾脏  

TRP super family and kidney

作　　者：朱斌[1] 陈楠[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院肾脏科,上海200025

出　　处：《国际病理科学与临床杂志》2007年第2期179-184,共6页Journal of International Pathology and Clinical Medicine

摘　　要：TRP(Transient receptor potentical)家族是非选择性阳离子通道家族,近来发现其与肾脏关系密切,如调节肾小管离子转运,肾脏微循环等。TRP通道异常可导致遗传性局灶节段硬化性肾病(FSGS),常染色体显性遗传多囊肾(ADPKD),低镁血症继发低钙血症(HSH)等,对TRP通道的进一步研究将有助于临床肾脏病的防治。TRP channels （Transient receptor potentical） including several subfamilies are nonselective cation channels. Recently they were found to be associated with kidney physiological regulation such as adjusting ionic transport in renal tubule and renal microcirculation. The abnormality of TRP channels can lead to some renal diseases such as familial FSGS, ADPKD, and HSH. Further researches on TRP channels would benefit the therapy and preclude of renal disease.

关 键 词：离子通道 TRP通道 肾疾病 

分 类 号：R692[医药卫生—泌尿科学]