厚朴活性成分对致龋菌生长和产酸影响的体外研究  

Effects of the Active Compounds of M.officinalis on Cariogenic Bacteria

作　　者：冯瑾[1] 李继遥[1] 周学东[1] 

机构地区：[1]四川大学华西口腔医学院口腔生物医学工程教育部重点实验室

出　　处：《四川大学学报（医学版）》2007年第3期456-458,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30430800)资助

摘　　要：目的研究厚朴活性成分对口腔致龋菌生长、代谢的影响。方法利用MBECTM-Device研究厚朴酚及和厚朴酚对5种主要致龋菌生长和代谢的影响,测定药物对细菌的最小抑菌浓度(MIC)和细菌生物膜的最低清除浓度(MBEC),并在低于MIC的药物浓度下观察其对致龋菌产酸能力的影响。结果厚朴酚及和厚朴酚对5种口腔浮游细菌及生物膜细菌均有良好的抑制作用,并对实验细菌产酸也有不同程度的抑制。结论厚朴活性成分可影响致龋菌生长代谢,可能是一种天然防龋药物,值得进一步深入研究。Objective To investigate the effects of the principal biologically active compounds of M. officinalis on the growth and acid generation of the main eariogenie bacteria. Methods Streptococcus mutans, Streptococcus sanguis, Actinomyces naeslundii, Actinomyces viscosus, Lactobacillus rhamnosus were chosen as the experimental bacteria. The active compounds （Magnolol and Honokiol） were separated from M, officinalis and then the effects of the two agents on the growth and acid generation of the bacteria were assessed. The minimal inhibitory concentration （MIC） and the minimal biofilm eradication concentration （MBEC） of the test strains were determined by MBECXM-Deviee. Results It was found that the growth of not only plantonic bacteria but also the biofilm were efficiently inhibited by Magnolol and Honokiol. The two agents could also inhibit the acid production of the test strains. Conclusion M. officinalis may be an effective anti-caries agent, and further researches will be necessary to define its usefulness in this aspect.

关 键 词：厚朴 厚朴酚 和厚朴酚 致龋菌 产酸 

分 类 号：R285[医药卫生—中药学]