南蛇藤属植物化学成分研究进展  

Chemical constituents of genus Celastrus

作　　者：冯卫生[1] 郝志友[1] 郑晓珂[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中国新药杂志》2007年第9期672-677,共6页Chinese Journal of New Drugs

基　　金：教育部科学技术研究重点资助项目(2003078)

摘　　要：卫矛科南蛇藤属植物全世界约有50种,我国约30种,广泛分布于各省,其中有15种入药,用于祛风除湿、行气散血、消肿解毒,治疗风湿筋骨疼痛、跌打损伤等。近年来国内外学者对本属植物的研究日趋活跃,其化学成分及药理活性研究取得较大进展。从本属植物分得大量β-二氢沉香呋喃型倍半萜类化合物,并分得一些二萜、三萜、黄酮、生物碱及其他类化合物,药理研究表明多个成分具有昆虫拒食、杀虫、抗炎、抗氧化、抗肿瘤、抗病毒、细胞毒等活性。其杀虫和昆虫拒食活性对于保护环境、降低农产品有毒残留物具有重要意义,目前已有这方面的植物源农药产品问世。而其他药理活性将使本属植物在防病治病方面大有作为。现对自2001年南蛇藤属植物的化学成分进行分类汇总,为本属植物的进一步研究提供参考。The best-known plant genus Celastrus contains 50 species or so over the world. Of the 30 species of Celastrus distributed in China, 15 species with functions of expelling wind-dampness, promoting qi and circulation, and removing blood stasis and toxins have been used as traditional herbal medicines in the relief of rheumatic muscle and joints pain and the treatment of traumatic injury. Large quantity of newly-emerging bioactive constituents from species of Celastrus spp. suggested the plant genus as increasing focuses of intensive investigations by botanists and chemists all over the world. The unique distribution of sesquiterpenoids with β-dihydroagarofuran skeleton together with other types of active principles, such as diterpenoids, triterpenoids, flavonoids and alkaloids, has entitled the plant genus to serve several different bioactivities including antifeedent, insecticidal, antitumour, antivirus, antioxidant and cytotoxicity. The antifeedent and insecticidals of these bioactive agents are of significance in the environmental protection and reduction of residual toxins in farm goods. Some botanical pesticides originated from the constituents of genus Celastrus are on marketing. This paper reviews categorization of chemical constituents found from species of Celastrus spp. since 2001.

关 键 词：南蛇藤属 化学成分 倍半萜 

分 类 号：R282.71[医药卫生—中药学] R284.2[医药卫生—中医学]