原子吸收分光光度法测定雷尼酸锶的含量  

Determination of strontium ranelate by atomic absorption spectrophotometry

作　　者：丁翔宇[1] 蒋晔[1] 李艳荣[1] 郝福[1] 

机构地区：[1]河北医科大学药学院,石家庄050017

出　　处：《药物分析杂志》2007年第4期575-577,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立原子吸收分光光度法测定雷尼酸锶含量的方法。方法:样品不经消化;在含有1.488g·L^(-1) EDTA-2Na及0.076g·L^(-1)氯化钾的0.15%的硝酸中,火焰法测定样品中锶的含量,并以锶的含量计算雷尼酸锶含量。结果:锶的线性范围为2～10μg·mL^(-1),回归方程为A=5.57×10^(-2)C+0.0028,r=0.9999;高、中、低三浓度的回收率分别为103.1%,97.5%,101.5%,RSD分别为2.7%,2.8%,3.1%;最低检出限为0.02μg·mL^(-1)。结论:该方法简单、快速、准确,可用于评价雷尼酸锶质量。Objective：To establish a method of the determination of strontium ranelate by atomic absorption spectrophotometry. Method：Without sample assimilation, strontium was directly determinated by atomic absorption spectrophotometry in the 0. 15% nitric acid which contained 0. 076 g L^-1KCl and 1. 488 g · L^-1 EDTA -2Na. The content of strontium ranelate was calculated on strontium. Result：The linear equation of strontium was A = 5.57 × 10^-2 C ＋ 0. 0028, the relation coefficient was 0. 9999 in the range of 2 - 10 g · mL^- 1 ;the recoveries at different concentration were 103.1% ,97.5% , 101.5, respectively, RSD were 2.7%, 2.8%, 3.1% , respectively; the limit of detection was 0. 02 μg·mL^-1. Conclusion： The method is simple, rapid, and accurate. It can be used to evaluate the quality of strontium ranelate.

关 键 词：原子吸收分光光度法 雷尼酸锶 含量测定 

分 类 号：R917[医药卫生—药物分析学]