脑心通片的薄层鉴别和定量测定研究  

Studies of TLC and Quantitative Determination for Naoxintong Pian

作　　者：韩桂茹[1] 赵志军[1] 

机构地区：[1]河北省药品检验所,河北石家庄050011

出　　处：《中国药品标准》2007年第2期39-43,共5页Drug Standards of China

摘　　要：目的：制定简便、快捷的脑心通片质量控制方法。方法：采用TLC，在4块薄层板上鉴别了当归、川芎、乳香、没药、丹参、桂枝、黄芪和芍药。用高效液相法测定了制剂中芍药苷的含量。结果；通过方法学考察，芍药苷的进样量在0．0346-0．3787／Lg，与峰面积呈良好的线性关系。芍药苷的平均回收率为99．05％（n=9），RSD为0．88％。TLC鉴别阴性无干扰。结论：制剂中多成分的鉴别和含量测定简便、快捷、实用。Objective：To establish a simple and rapid method for the quality control of Naoxintong Pian. Method：Radix Angelicae Sinensis, Rhizoma Chuanxiong, Olibanum, Myrrha, Radix, Salviae Miltiorrizae, Ramulus Cinnamomi, Radix Astragali and Radix Paeoniae Rubra were identified by TLC at four thin-layer chromatographic plates. The contents of paeonioflorin in this preparation were determinated by HPLC. Results：The methodological study showed that a good linear correlation existed in the range of 0. 0346-3. 787/Lg for paeonioflorin. The average recovery of paeonioflorin was 99.05% （n= 9）. RSD was 0. 88%. The negative sample didn＇t interfere the identification of TLC. Conclusion：The identification and Content determination of multicomponent in preparation is simple,rapid and usable.

关 键 词：脑心通片 芍药苷 含量测定 HPLC TLC 

分 类 号：R284[医药卫生—中药学]