苯中毒致再生障碍性贫血的细胞免疫功能研究  

Immunological function of T lymphocytes in benzene poisoning-induced aplastic anemia

作　　者：闫春平[1] 闫玲[1] 李晶[1] 李书敏[1] 

机构地区：[1]滨州市中心医院血液科

出　　处：《临床血液学杂志》2007年第3期146-148,共3页Journal of Clinical Hematology

摘　　要：目的:探讨细胞免疫功能与苯中毒性再生障碍性贫血(再障)发生、发展及转归的关系。方法:根据16例苯中毒再障患者T淋巴细胞亚群有无异常,分为A组和B组。T细胞亚群正常的患者为A组,CD4+/CD8+比值降低者为B组。A组应用雄激素、粒细胞集落刺激因子(G-CSF)和促红细胞生成素(Epo)联合治疗,B组应用以上方案联合环孢素A(CsA)治疗。外周血细胞水平恢复正常后G-CSF、Epo及CsA逐渐减量。结果:所有病例治疗后外周血细胞计数、骨髓涂片正常,治疗前CD4+/CD8+降低者,治疗后恢复正常。结论:部分苯中毒性再障患者,即使无免疫抑制剂的应用,造血干细胞的损伤也能逐渐恢复。因此,对苯中毒性再障患者,常规检查外周血T淋巴细胞及其亚群的变化,以预测应用免疫抑制剂的可行性及其有效性。Objective：To explore the relationship of the cellular immunological function with accurrence, progress, prognosis, outcome of benzene poisoning-induced aplastic anemia（BPAA）. Method： 16 patients with BPAA were divided into A group and B group by the changes in Peripheral blood T-lymphocyte subsets. The T-lymphocyte subsets were normal in patients of A group, whereas CD4^＋ was lower ,CD8^＋ was significantly higher and the CD4^＋/CD8^＋ obviously reduced in all patients of B group. Androgens ,granulocyte colony-stimulating factor （GCSF） and erythropoietin （Epo） were administered to A group, whereas the cases of B group were treated with androgens,G-CSF,Epo and CsA. Result： All examinations including blood count, bone marrow biopsy and T cell subpopulation restored to normal in all patients after therapy. Conclusion： The destruction of hematopoietic stem cells induced by benzene can recover gradually in some patients even without immunosuppressive treatment. Peripheral blood T lymphocyte and their subsets should be routinely examined in all of the BPAA patients diagnosed so as to assess the indication and predict the effectiveness of immunosuppressive therapy.

关 键 词：贫血 再生障碍性 苯中毒 免疫功能 淋巴细胞 

分 类 号：R556[医药卫生—血液循环系统疾病]