益气活血解毒汤对实验性动脉粥样硬化家兔血脂、NO、ET-1、MDA及SOD的影响  

The Effects of Yiqihuoxuejiedu Decoction on the Levels of Blood Lipids,Nitric Oxied(NO), Endothelin(ET), Superoxide-dismutase(SOD) Activity and Malondialdehyde(MDA) in Experimental Atherosclerotic Rabbits

作　　者：褚福永[1] 胡业彬[2] 

机构地区：[1]安徽中医学院,硕士生合肥230038 [2]安徽省中医院,合肥230031

出　　处：《中国中医急症》2007年第5期576-578,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：安徽省教育厅自然科学基金项目(No.2006KJ340B)

摘　　要：目的观察益气活血解毒汤对实验性动脉粥样硬化(AS)家兔血脂、一氧化氮(NO)、内皮素(ET-1)、脂质过氧化产物(MDA)及超氧化物歧化酶(SOD)的影响。方法24只雄性日本大耳白兔随机分为空白对照组、模型对照组、益气活血解毒汤组、辛伐他汀组,高脂饲料喂饲复制AS模型;10周后测定各组家兔上述指标。结果与模型对照组相比,益气活血解毒汤组TG、TC、LDL、MDA、ET-1含量明显下降,NO、HDL含量明显升高,SOD活性升高。结论益气活血解毒汤有明显的抗家兔AS形成的作用,可能与其降低血脂、改善内皮细胞功能、减轻过氧化损伤等因素有关。Objective： To observe the effects of Yiqihuoxuejiedu Decoction （益气活血解毒汤） on the levels of blood lipids, nitric oxide（NO）, endothelin（ET）, superoxide - dismutase（SOD） activity and malondialdehyde（MDA） in experimental atherosclemtic rabbits. Methods： 24 male Japanese big - ear - rabbit were randomly divided into 4 groups, the control group, the model group, Yiqihuoxuefiedu Decoction group, and simvastatin group. The atherosclerotic rabbit model was established by feeding rabbits with high cholesterol diet. Each biochemical parameter above was measured after 10 weeks treatment. Results： The levels of serum TC, TG, MDA, ET - 1 were significantly decreased while the levels of serum NO, SOD activities were increased compared with the model gorap. Conclusion： Yiqihuoxuejiedu Decoction can significantly inhibit atherosclerosis in experimental atherosclerotic rabbits. The effect may related to decrease blood lipids, presere vascular endothelial cells function and antioxidation.

关 键 词：动脉粥样硬化 益气活血解毒汤 家兔 

分 类 号：R285.5[医药卫生—中药学]