抵当口服液对大鼠脑出血模型c-fos蛋白表达及脑水肿指数的影响  

The Influence of Didang Oral Solution on the Expression of C-fos Protein and Encephaledema Index in Rats with Cerebral Hemorrhage

作　　者：张小萍[1] 吴颢昕[2] 刘韶华[3] 林靓[2] 何文彬[2] 

机构地区：[1]南京中医药大学第一附属医院,南京210029 [2]南京中医药大学基础医学院,南京210029 [3]东南大学附属中大医院,南京210009

出　　处：《中国中医急症》2007年第5期579-580,595,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：江苏省科技厅社会发展基金项目(BS2000-82);江苏省教育厅自然科学基金项目(No.03KJB60096)

摘　　要：目的探讨抵当口服液对脑出血后脑组织的保护机制。方法采用Nath改良法建立脑出血模型,用免疫组织化学方法观察脑出血后c-fos蛋白的表达及脑水肿指数。结果与生理盐水组相比,模型组脑组织含水量较高;抵当口服液组脑组织含水量较模型组低。与生理盐水组相比,模型组c-fos表达明显增高;与模型组相比,抵当口服液组c-fos表达明显降低。结论抵当口服液可能通过抑制脑出血后脑组织中c-fos蛋白的表达,减轻脑水肿的发生。Objective： To investigate the protective mechanism of Didang Oral solution（抵当口服液） on brain with cerebral hemorrhage. Methods： After the establishment of the rat models with cerebral hemorrhage using modified Nath methods, the expression of c- fos protein and encephaledema index were observed with immunohistochemistry（IHC）. Results： Compared with the physiological saline group, the brain moisture content of the model group was higher, and that of the D/dang group was lower than that of the model group. And while the expression of the c - los protein of model group significantly increased compared with the physiological saline group, and that of the Didang group was lower than that of the model group. Conclusion： Didang Oral Solution could decrease the encephaledema, which may be via decreasing the expression of c - fos protein.

关 键 词：脑出血 抵当口服液 C-FOS 脑水肿脂数 大鼠 

分 类 号：R285.5[医药卫生—中药学]