黄芪多糖对糖尿病足溃疡渗出液成纤维细胞MMP-2、MMP-9表达的影响  

Effects of Astragalus Polysaccharides on the expressions of MMP-2 and MMP-9 in human dermal fibroblasts from diabetic foot ulcer transudate

作　　者：张正军[1] 肖正华[1] 陈定宇[1] 周倩[1] 黄春苓[1] 何凌[1] 徐琳[1] 

机构地区：[1]广州市第一人民医院内分泌科,山东省济宁医学院附属医院510180

出　　处：《中国糖尿病杂志》2007年第4期202-203,共2页Chinese Journal of Diabetes

基　　金：广东省中医药局立项科研课题资助项目(400008)

摘　　要：糖尿病足溃疡渗出液中的IL-1β显著高于急性伤口,50μg/LIL-1β显著增加足溃疡渗出液中成纤维细胞MMP-2、MMP-9的活性及其蛋白表达,100mg/L黄芪多糖可降低MMP-2、MMP-9活性及其蛋白的表达,也可降低50μg/LIL-1β所致的MMP-2、MMP-9高活性及其蛋白高表达。There was a significantly increased concentration of IL-1β in wound transudate from diabetic foot ulcers, compared with acute diabetic traumatic wounds. The activity and protein expression of MMP-2 and MMP-9 in supernatant of fibroblast culture were significantly higher in 50μg/L of IL-1β group, and lower significantly in 100 mg/L of Astragalus Polysaccharides （AP） group, compared with control group. The activities and protein expressions of MMP-2 and MMP-9 were significantly lower in combination group of 50 μg/L IL-1β and 100 mg/L AP than those in 50 μg/L IL-1β group and in control group.

关 键 词：糖尿病足部溃疡 成纤维细胞 白介素-1Β 基质金属蛋白酶 

分 类 号：R285.5[医药卫生—中药学]