糖尿病急性代谢并发症与非创伤性横纹肌溶解症  

Acute metabolic complications of diabetes mellitus and noninjuria rhabdomyolysis

作　　者：白秀燕[1] 闫蓓[1] 陈丽[2] 

机构地区：[1]山东省警官总医院内分泌科,济南250002 [2]山东大学齐鲁医院内分泌科,济南250012

出　　处：《国际内分泌代谢杂志》2007年第3期178-180,共3页International Journal of Endocrinology and Metabolism

摘　　要：糖尿病酮症酸中毒（DKA）与高渗性高血糖状态（HHS）是糖尿病最为严重的急性代谢并发症,在DKA或HHS患者中有50%可合并非创伤性横纹肌溶解症（NRML）,严重者可导致急性肾功能衰竭。DKA或HHS介导NRML的机制可能包括肌肉缺血、缺氧,电解质紊乱及酸碱失衡,感染,应用羟甲戊二酸单酰CoA还原酶抑制剂等。因早期诊断并及时治疗常可逆转病情发展,从而避免发生严重并发症,降低死亡率,因此对NRML及时并准确的诊断很重要。Diabetic ketoacidosis（DKA） and hyperosmolar hyperglycemic state（HHS） are acute metabolic complications of diabetes mellitus. Noninjuria rhabdomyolysis（NRML） occurs in as many as 50% of patients presenting with DKA or HHS and may induce acute renal failure. The mechanism of DKA or HHS-mediated muscle injury is uncertain. Theories include insufficient energy and oxygen delivery to muscle, electrolyte disturbances, acid-base imbalance, infection, treating with HMG-CoA reductase inhibitors, etc. Timely and accurate diagnosis of NRML is important, because significant potential complications may be averted with appropriate therapy.

关 键 词：糖尿病酮症酸中毒 高渗性高血糖状态 非创伤性横纹肌溶解 急性肾功能衰竭 

分 类 号：R6[医药卫生—外科学] R587[医药卫生—临床医学]