阿司匹林抵抗和基因多态性  

Aspirin Resistance and Genetic Polymorphisms

作　　者：王蓓芸[1] 谈世进[1] 

机构地区：[1]上海交通大学附属第六人民医院老年科,上海200233

出　　处：《心血管病学进展》2007年第3期490-493,共4页Advances in Cardiovascular Diseases

摘　　要：阿司匹林具有抗血小板聚集的作用,但一些规则服用阿司匹林患者仍然发生了血管栓塞事件,也就是存在阿司匹林抵抗现象。虽然目前阿司匹林抵抗的发生机制尚不明确,但基因多态性与阿司匹林抵抗的发生有一定的关系。目前研究的基因多态性包括:血小板糖蛋白(GP)Ⅱb/Ⅲa基因多态性、环氧合酶(COX-1)基因的多态性、血小板糖蛋白GPⅠa/Ⅱa受体基因多态性、ADP受体P2Y1基因的变化等。Aspirin is an effective anti - platelet agent. However, some individuals suffer atherothrombotic events, despite taking aspirin regularly. They appear to have ＂aspirin resistance＂ （ AR）. The mechanisms of AR are as yet unclear to researchers, although it is known that there is a relationship between genetic polymorphisms and AR. The polymorphism may involve： polymorphism of the gene encoding glycoprotein Ⅲa （GPⅢa） ; polymorphism on the cyclooxygenase-1 gene; polymorphism of platelet GP Ⅰ a/Ⅱ a collagen-receptor gene; polyraorphism of P2YI gene.

关 键 词：阿司匹林 基因多态性 

分 类 号：R971.1[医药卫生—药品]