九牛造化学成分研究  

Study on Chemical Constituents of Euphorbia hylonoma Hand.-Mazz.

作　　者：郭增军[1] 佐建峰[1] 卜筱茜[1] 孙启时[2] 

机构地区：[1]西安交通大学医学院药学系,陕西西安710061 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中药材》2007年第4期412-415,共4页Journal of Chinese Medicinal Materials

基　　金：陕西省自然科学基金(编号:2004C229)

摘　　要：目的:研究九牛造根中的化学成分。方法:采用硅胶柱层析和葡聚糖凝胶柱层析分离纯化技术,通过理化性质和波谱特征分离并鉴定化合物。结果:从九牛造根的丙酮提取物中分离鉴定出8个化合物,分别为大戟甾醇(eupholⅠ)、5-羟甲基糠醛(5-hydroxymethylfuraldehydeⅡ)、β-谷甾醇(β-sitosterolⅢ)、β-胡萝卜苷(β-sitosterolglucosideⅣ)、3,3′,4-三甲基鞣花酸(3,3′,4-tri-o-methylellagic acidⅤ)、3,3′-二甲基鞣花酸(3,3′-di-methylellagicacidⅥ)、3,3′-二甲基鞣花酸-4′-β-D-木糖苷(3,3′-di-methylellagic acid-4′-o-β-dxylopyranosidⅦ)、没食子酸(gallicacidⅧ)。结论:所分离得到的化合物Ⅱ、Ⅵ、Ⅶ、Ⅷ为首次从该植物中分离得到。Objective： To study the constituents of the roots of Euphorbia hylonoma Hand. -Mazz. Methods： The chemical constituents were isolated and purified by solvent extraction together with various chromatographic techniques, the structures were elucidated on the basis of chemical properties and spectral data. Results： Eight compounds were isolated from the acetone extracts of the roots of Euphorbia hylonoma Hand-Mazz., which were euphol（Ⅰ）,5-hydroxymethylfuraldehyde（Ⅱ）, β-sitosterol（Ⅲ ）, β-sitosterol glucoside （Ⅳ）, 3,3＇, 4-tri-o-methylellagic acid （Ⅴ）, 3,3＇ tdi-o-methylellagic acid （Ⅵ）, 3,3 ＇-di-o-methylellagic acid4＇-o-β-dxylopyranosid （Ⅶ）, gallic acid（Ⅷ）. Conclusion： The compounds Ⅱ,Ⅵ,Ⅶ,Ⅷ were isolated from Euphorbia hylonoma Hand-Mazz. for the first time.

关 键 词：九牛造 化学成分 湖北大戟 

分 类 号：R284.1[医药卫生—中药学]