穿心莲片在健康人体内的药物动力学研究  

Pharmacokinetics of Chuanxinlian Tablet in Healthy Chinese Volunteers

作　　者：洪馨[1] 黄天来[1] 宓穗卿[1] 叶少梅[1] 欧卫平[1] 王宁生[1] 

机构地区：[1]广州中医药大学临床药理研究所,广东广州510405

出　　处：《中药材》2007年第4期439-441,共3页Journal of Chinese Medicinal Materials

基　　金：广东省科技攻关项目(20021909)

摘　　要：目的:研究穿心莲片中脱水穿心莲内酯在中国健康志愿者体内的药物动力学。方法:8名男性健康志愿者,单剂量口服穿心莲片2片,用高效液相色谱-质谱联用法测定血浆中脱水穿心莲内酯的含量,用PK Solution软件计算药物动力学参数。结果:穿心莲片中的脱水穿心莲内酯主要药动学参数tmax,Cmax,t1/2ka,t1/2α,t1/2β,AUC0-t分别为(1.50±0.21)h,(147.30±53.29)μg.L-1,(0.51±0.28)h,(0.60±0.33)h,(3.62±1.16)h,(256.63±64.18)μg.h.L-1。结论:穿心莲片中脱水穿心莲内酯在体内吸收迅速,达峰较快,消除半衰期较长,结果可为穿心莲片在临床用药的安全和有效提供实验依据。Objective ：To study pharmacokinetics of debydroandrographolide, that is a main active component in Chuanxinlian tablet, in healthy Chinese volunteers. Methods ： Eight volunteers were chosen for a single dose of two Chuanxinlian tablet drug concentrations in plasma were measured by HPLC-MS method and the pharmacokinetic parameters were calculated by PK Solution 2.0 software. Results：t1/2ka,t1/2α,t1/2β,Cmax, tmax and AUC0-t were（O. 51 ±0.28） h, （0.60 ±0.33） h, （3.62 ± 1.16）h, （147.30 ± 53.29 ） μg· L^-1 , （ 1.50 ± 0. 21 ） h, and （ 256.63 ± 64. 18 ）μg ·h · L^-1 , respectively. Conclusion ： Dehydroandrographolide has rapid absorption and long elimination rate after oral administration. The results can provide an evidence for the safety and efficiency of Chuanxinlian tablet in clinical application.

关 键 词：穿心莲片 脱水穿心莲内酯 药物动力学 高效液相色谱-质谱 

分 类 号：R285.55[医药卫生—中药学]