[2-(氟代苯氧)丙酰氧基]取代甲基膦酸二甲酯的合成与除草活性  

Synthesis and Herbicidal Activity of α-[2-(Fluorosubstituted phenoxy) propionyloxy]alkylphosphonates

作　　者：李艳军[1] 段吉平[1] 贺红武[1] 

机构地区：[1]华中师范大学化学学院教育部农药与化学生物学重点实验室

出　　处：《应用化学》2007年第5期596-598,共3页Chinese Journal of Applied Chemistry

基　　金：国家重点基础研究计划--"九七三"计划资助项目(2003CB114400);国家自然科学基金资助项目(20372023)

摘　　要：通过2种2-(氟代苯氧)丙酸(Ⅰ)转化为相应的酰氯,再通过酰氯分别与4种α-羟基膦酸酯(Ⅱ)的缩合反应,将含氟基团引入到α-氧代烃基膦酸酯的骨架中,合成了8个新的α-[2-(氟取代苯氧)丙酰氧基]烃基膦酸酯,收率为20%～71%。经1H NMR、IR和MS测试技术对所有化合物进行了结构表征。初步的生物活性测试表明,部分化合物对单、双子叶植物根的生长具有优异的抑制作用。质量浓度分别为100和10 mg/L时,化合物Ⅲe～Ⅲh对油菜根和稗草根的生长抑制率均超过93%。In order to find new phosphonates with better herbicidal activity, fluorous group was introduced to α-oxophosphonates. Eight novel phosphonate derivatives were synthesized by the condensation reaction of 2- （fluoro-substituted phenoxy ）propionyl chloride with α-hydroxyphosphonates in chloroform under reflux in yields of 20% - 71%. The molecular structures of all the compounds were confirmed by IR, ^1H NMR and MS. Preliminary bioassay results show that some of these compounds have better inhibiting effect against the roots of monocotyledon and dicotyledon. Inhibitory rates of compounds Ⅲ e - Ⅲh against the roots of rape and barnyard grass were more than 93%.

关 键 词：膦酸酯 氟取代基 合成 除草活性 

分 类 号：O621.2[理学—有机化学]