高敏感C反应蛋白与外周动脉疾病的关系  

The relationship between high-sensitivity C-reactive protein and peripheral artery disease

作　　者：刘浩[1] 余金明[1] 李觉[1] 田巨龙 张汝林 崔思芳 仝其广[4] 郑黎强[1] 罗盈怡[1] 李宪凯[5] 胡大一[5] 

机构地区：[1]同济大学医学院预防医学教研室,上海200092 [2]四川省攀枝花市市中心医院 [3]四川省攀枝花市盐边县鱼门镇医院 [4]首都医科大学北京同仁医院心内科 [5]同济大学医学院心肺血管中心,上海200092

出　　处：《中华内科杂志》2007年第5期373-375,共3页Chinese Journal of Internal Medicine

摘　　要：目的探讨高敏感 C 反应蛋白(hs-CRP)与外周动脉疾病(PAD)的关系。方法 2005年7月对攀枝花市某社区年龄>40岁的符合人选标准的643例居民进行流行病学研究。结果吸烟、高血压、糖尿病、低 HDL-C 以及心血管疾病史的比例均为 PAD 组高于非 PAD 组。高血压、糖尿病和心血管疾病史的比例均呈现 CRP 高浓度组高于低浓度组。多因素分析发现,CRP 中、高浓度组的OR 值是低浓度组的2倍多;对 hs-CRP 进行对数变换后分析,发现 Log(hs-CRP)和 PAD 仍然呈正向关系(P=0.007)。结论 hs-CRP 和 PAD 的发生相关,升高的 hs-CRP 是 PAD 的独立危险因素。Objective To investigate the association between high-sensitivity C-reactive protein and peripheral arterial disease. Methods The study population comprised 643 subjects aged at least 40 years in whom both CRP and ankle-brachial index were measured. The survey included information on demographic characteristics, clinical examinations and ankle-brachial index （ABI）. Ankle-brachial index （ABI） 〈 0.9 was diagnostic of PAD. Results 64 subjects （ 10% ） were diagnosed as PAD. The prevalence of current smoking, hypertension, diabetes, low HDL cholesterol and history of cardiovascular disease in the participants with PAD were higher than without （ P 〈 0. 05 ）. The prevalence of hypertension, diabetes, and history of cardiovascular disease was higher in subjects with high CRP （ P 〈 0. 05 ）. In logistic regression analyses, the moderate CRP group and high CRP group had a two-fold higher OR compared with the low CRP group. The P-trend across CRP groups was statistically significant （ P = 0.036 ）. High log-transformed hs- CRP level was significantly related to PAD after adjustment for the cardiovascular risk factors mentioned above （P = 0. 007）. Conclusion hs-CRP is related to PAD and high level hs-CRP is an independent risk factor for PAD in Chinese adults aged 40 years and more.

关 键 词：C反应蛋白 动脉硬化 踝臂指数 

分 类 号：R543.5[医药卫生—心血管疾病]